New trials, publications, preprints and grants on this target, month by month.
Publication
Calycosin Promotes Ferroptosis in Cervical Cancer via the AMPK/PI3K-TFEB-Autophagy-Lysosome Axis.
1 Nov 2026· Journal of cellular biochemistry· PUBMED
Publication
Correction: Novel exosomal circEGFR facilitates triple negative breast cancer autophagy via promoting TFEB nuclear trafficking and modulating miR-224-5p/ATG13/ULK1 feedback loop.
1 Nov 2026· Oncogene· PUBMED
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Light Microscopy-Based Techniques to Identify TFEB-Altered Renal Cell Carcinoma: A Comparison Study With TFE3-Rearranged Renal Cell Carcinoma and Common Renal Cell Tumors.
28 Oct 2026· The American journal of surgical pathology· PUBMED
Publication
Integrated Computational Pharmacology and Experimental Validation Identify the PLK2-TFEB Axis as a Therapeutic Mechanism of Kunkui Baoshen Decoction in Diabetic Kidney Disease.
23 Oct 2026· Current pharmaceutical design· PUBMED
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Development of DCL1191 as a Potent, Selective and Orally Bioavailable Inhibitor for Autophagy-Associated Transcription Factor EB (TFEB).
22 Oct 2026· Journal of medicinal chemistry· PUBMED
Publication
Xanthoangelol-enriched Angelica keiskei Koidzumi targets foamy Kupffer cells to ameliorate MASLD by activating the TFEB-mediated CLEAR network.
17 Oct 2026· International immunopharmacology· PUBMED
Publication
Gigantol Ameliorates High-Fat and High-Fructose Diet-Induced Chronic Kidney Disease by Promoting TFEB-Mediated Mitophagy to Suppress Ferroptosis.
14 Oct 2026· Journal of agricultural and food chemistry· PUBMED
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TFEB-Amplified Renal Cell Carcinoma With Focal Rhabdoid Features, Hyaline Globules, Giant Tumor Cells, and Osseous Metaplasia.
9 Oct 2026· International journal of surgical pathology· PUBMED
Publication
TFEB promotes the progression of t(6; 11) translocation renal cell carcinoma by upregulating LINC00612 expression.
3 Oct 2026· Medical oncology (Northwood, London, England)· PUBMED
Publication
A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation.
30 Sept 2026· Nature· PUBMED
Publication
mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation.
25 Sept 2026· Science advances· PUBMED
Publication
Nuciferine Ameliorates Ovariectomy-Induced Bone Loss via TFEB-Mediated Autophagy-Lysosomal Pathway.
21 Sept 2026· Biomolecules· PUBMED
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Exploring the Neuroprotective Effects of Walnut (Juglans regia L.) Against Cognitive Impairment in Alzheimer's Disease Through the MAPK-mTORC1-TFEB-Mediated Endolysosomal Pathway: A Network Pharmacology and Molecular Docking Approach.
17 Sept 2026· International journal of molecular sciences· PUBMED
Publication
Disrupted TFEB/GDNF-cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice.
16 Sept 2026· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publication
Rg3 suppresses gastric cancer progression via TFEB-mediated lysosomal autophagy pathway.
13 Sept 2026· Cellular signalling· PUBMED
Publication
Enhancing lysosome function via TFEB activation reduces lipofuscin-like granules in the retinal pigment epithelium.
26 Aug 2026· Experimental eye research· PUBMED
Publication
Lutein Attenuates Lipid Accumulation in Association with TFEB Nuclear Translocation and Autophagy-Lysosomal Responses in a Cellular Model of Hepatic Steatosis.
21 Aug 2026· Antioxidants (Basel, Switzerland)· PUBMED
Publication
Dual-Pathway Astrocyte Failure in Parkinson's Disease: Therapeutic Targeting of Nrf2/TFEB Suppression and cGAS-STING/Ferroptosis Activation.
19 Aug 2026· Molecular neurobiology· PUBMED
Publication
α-Asarone attenuates synaptic loss in APP/PS1 mice by restoring microglial phagocytic-lysosomal balance via the SPP1-mTOR-TFEB axis.
13 Aug 2026· Phytomedicine : international journal of phytotherapy and phytopharmacology· PUBMED
Publication
Genkwanin mitigates renal fibrosis by reprogramming profibrotic signaling and restoring TFEB-mediated autophagy.
13 Aug 2026· Frontiers in pharmacology· PUBMED
Publication
Clinicopathological and molecular comparison of eosinophilic solid and cystic renal cell carcinoma and TFEB-amplified renal cell carcinoma: a comprehensive study of 15 cases.
13 Aug 2026· Histopathology· PUBMED
Publication
Noncanonical mTORC1-TFEB activation promotes hepatocyte plasticity and high-grade malignancy in hepatocellular carcinoma.
6 Aug 2026· The Journal of clinical investigation· PUBMED
Publication
CD19 CAR-macrophage suppressed the progression of DLBCL via modulating SYK/SHP2/TBK1/TFEB signaling.
4 Aug 2026· Biochemical and biophysical research communications· PUBMED
Publication
TFEB at the Crossroads: From Cellular Mechanism to Precision Care.
30 Jul 2026· Circulation research· PUBMED
Publication
TRPM2 Promotes Lipophagy Through TFEB and LAL in HFD-Fed Mice.
28 Jul 2026· Cells· PUBMED
Publication
Retraction notice to "Molecular mechanisms of MAPK9, BAX, and TFEB proteins: Genetic correlations between oxidative stress and autophagy pathways in Alzheimer's disease" [Int. J. Biol. Macromol. 309 (2025) 143196].
22 Jul 2026· International journal of biological macromolecules· PUBMED
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Targeting eIF5A2 hypusination with bikinin sensitizes hepatocellular carcinoma to lenvatinib by suppressing TFEB-mediated autophagy.
18 Jul 2026· Human cell· PUBMED
Publication
Liver-to-kidney apolipoprotein J trans-accumulation exacerbates diabetic renal injury by disrupting TFEB-mediated lipid homeostasis.
17 Jul 2026· Diabetologia· PUBMED
Publication
Schizophrenia and bipolar disorder risk gene AKAP11 sustains cognitive function by regulating TFEB-mediated autophagy.
16 Jul 2026· Cell death and differentiation· PUBMED
Publication
HBx Downregulates TFEB via the CUL4A/CUL4B-DDB1 Axis to Disrupt Lysosomal Function in Hepatocellular Carcinoma Cells.
13 Jul 2026· Cells· PUBMED