New trials, publications, preprints and grants on this target, month by month.
Publication
CD226⁺TIGIT⁺ MAIT cells exhibit an increased relative frequency and a checkpoint-enriched phenotype in Sjögren's disease.
27 Oct 2026· Clinical rheumatology· PUBMED
Publication
Anbalcabtagene autoleucel (PD-1 and TIGIT knockdown CD19 CAR T-cell therapy) for relapsed or refractory LBCL: the CRC01-01 trial.
22 Oct 2026· Blood· PUBMED
Publication
Phenotypic Landscape of Programmed Death and TIGIT/CD155/DNAM-1 Pathways in NK Cells in Ovarian Cancer.
21 Oct 2026· Biomedicines· PUBMED
Publication
CTLA-4/PD-1, LAG-3, and TIGIT Inhibitors: Emerging Drug Targets and Combination Strategies in Hepatocellular Carcinoma.
20 Oct 2026· Current cancer drug targets· PUBMED
Publication
Higher TIGIT expression in the intraperitoneal immune microenvironment is associated with shorter progression-free survival in patients with gastric cancer with peritoneal metastasis treated with intraperitoneal paclitaxel.
16 Oct 2026· Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico· PUBMED
Publication
TNFα-driven epigenetic upregulation of TIGIT creates a targetable vulnerability in tumors.
12 Oct 2026· Oncogene· PUBMED
Publication
TIGIT+ B cells: emerging immunoregulatory players in autoimmunity and transplantation tolerance with therapeutic potential.
29 Sept 2026· Frontiers in immunology· PUBMED
Publication
TIGIT regulates CD8+T cell exhaustion via the PI3K/AKT-FOXO1-TOX axis in extrahepatic cholangiocarcinoma.
29 Sept 2026· Clinical immunology (Orlando, Fla.)· PUBMED
Publication
Adjuvant anti-TIGIT plus anti-PD-1 in melanoma: A necessary failure that clarifies the path forward.
28 Sept 2026· Translational oncology· PUBMED
Publication
Beyond PD-L1/PD-1: expression of PVR/TIGIT and TNFRSF14/BTLA axes in response to Helicobacter pylori and in gastric cancer lesions.
22 Sept 2026· ImmunoHorizons· PUBMED
Publication
Corrigendum to "Heterogeneous expression of predictive biomarkers PD-L1 and TIGIT in non-mucinous lung adenocarcinoma and corresponding lymph node metastasis: A challenge for clinical biomarker testing" [Neoplasia 38 (2023) 100884].
21 Sept 2026· Neoplasia (New York, N.Y.)· PUBMED
Publication
Immune checkpoint knockout screen reveals TIGIT-CD155 interaction as a significant modulator of adapter CAR-T cell function in acute myeloid leukemia.
17 Sept 2026· Oncoimmunology· PUBMED
Publication
TIGIT+ CD4+ T Cell Enrichment in Colorectal Liver Metastases Is Associated with Shorter Survival.
15 Sept 2026· Cancers· PUBMED
Publication
TIGIT at a crossroads: lessons from SKYSCRAPER-03 in unresectable stage III NSCLC.
11 Sept 2026· Annals of oncology : official journal of the European Society for Medical Oncology· PUBMED
Publication
The PVR-TIGIT/CD96/CD226 axis: a novel immune checkpoint target in ovarian cancer.
20 Aug 2026· Frontiers in immunology· PUBMED
Publication
Pharmacological inhibition of LSD1 suppresses the CD155/TIGIT immune checkpoint axis and enhances NK cell-mediated cytotoxicity in colorectal cancer.
11 Aug 2026· Bioorganic chemistry· PUBMED
Publication
The Right Key, the Wrong Lock: TIGIT Checkpoint Blockade and the Road to Precision Immunotherapy.
7 Aug 2026· Pharmaceutics· PUBMED
Publication
Anti-TIGIT in PD-L1-High Advanced Non-Small Cell Lung Cancer: Insights From SKYSCRAPER-01 and the Path Forward.
27 Jul 2026· Journal of clinical oncology : official journal of the American Society of Clinical Oncology· PUBMED
Publication
Artemisinin liposomes regulates breast cancer metastasis and apoptosis through TIGIT/CD155 signal axis.
27 Jul 2026· Apoptosis : an international journal on programmed cell death· PUBMED
Publication
Intratumoral TIGIT blockade augments antitumor responses and bypasses increased functionality of peripheral TIGIT+ NK cells in mouse and human models of bone and soft tissue sarcoma.
22 Jul 2026· Journal for immunotherapy of cancer· PUBMED
Publication
AdvanTIG-302: Phase 3 Study of Ociperlimab (Anti-TIGIT) Plus Tislelizumab (Anti-PD-1) Versus Pembrolizumab in Untreated, Locally Advanced, Unresectable, or Metastatic NSCLC With PD-L1 Expression of 50% or More.
14 Jul 2026· Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer· PUBMED
Publication
Dual TIGIT and PD-1 blockade in immunotherapy-refractory hepatocellular carcinoma: a signal beyond resistance?
1 Jul 2026· Hepatobiliary surgery and nutrition· PUBMED
Publication
Tumor lymph node metastasis chip reveals that the NECTIN3-TIGIT axis promotes melanoma metastasis by enhancing treg cell function and inducing CD8+ T cell exhaustion.
25 Jun 2026· Cellular oncology (Dordrecht, Netherlands)· PUBMED
Publication
Comprehensive Bioinformatic Characterization of CD70, CD80, and TIGIT as Diagnostic, Prognostic, and Immune Biomarkers in Pan-Cancer.
21 Jun 2026· Current issues in molecular biology· PUBMED
Publication
PD-1 and TIGIT coexpression enables selective enrichment of clonally expanded tumor-reactive CD8 T cells for melanoma TIL therapy.
17 Jun 2026· Journal of translational medicine· PUBMED
Publication
No RFS benefit found from adding vibostolimab to pembrolizumab in patients with high-risk melanoma: Adding the anti-TIGIT antibody vibostolimab to adjuvant pembrolizumab failed to improve recurrence-free survival and increased toxicity.
15 Jun 2026· Cancer· PUBMED
Publication
Beyond PD-1/PD-L1: Reprogramming the Gynecologic Tumor Microenvironment by Targeting TIGIT and Myeloid Suppression.
14 Jun 2026· International journal of molecular sciences· PUBMED
Publication
Peripheral immune profiling identifies CD8⁺ TEMRA and CD4⁺ T TIGIT⁺ cells as independent prognostic markers for first-line immune checkpoint inhibitors in advanced non-small cell lung cancer.
10 Jun 2026· Respiratory research· PUBMED
Publication
TIGIT expression dictates the immunosuppressive reprogramming of myeloid cells in glioblastoma.
1 Jun 2026· Neuro-oncology· PUBMED
Publication
NK Cell Profiling: Expression of TIGIT and LAG3 as Immune Checkpoints in Advanced Endometriosis.
1 Jun 2026· American journal of reproductive immunology (New York, N.Y. : 1989)· PUBMED