New trials, publications, preprints and grants on this target, month by month.
Publication
Atorvastatin inhibits PASMC proliferation in pulmonary hypertension via the TLR4/NF-κB/NLRP3/IL-1β pathway.
6 Nov 2026· Journal of cardiovascular pharmacology· PUBMED
Publication
Association of TLR2 T597C, TLR4 A896G, and TLR9 G1174A gene polymorphisms with risk of pulmonary tuberculosis in the Ethiopian population: A case-control study.
30 Oct 2026· PloS one· PUBMED
Publication
Integrative network pharmacology, machine learning, and experimental validation identify the TLR4/NF-κB/NLRP3 axis as a potential mechanism underlying the therapeutic effects of Lingguizhugan decoction in Alzheimer's disease.
29 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
Farrerol Attenuates Brain Injury After Intracerebral Hemorrhage and Modulates Nrf2 and TLR4/NF-κB Signaling.
29 Oct 2026· Molecular neurobiology· PUBMED
Publication
Tetrandrine attenuates diabetic kidney disease by suppressing the TLR4-NF-κB-NLRP3 inflammatory signaling pathway in proximal tubular cells.
27 Oct 2026· International immunopharmacology· PUBMED
Publication
Altered HMGB1-TLR4-NF-κB Signaling and regulatory microRNA expression in idiopathic generalized epilepsy according to Toxoplasma gondii serostatus.
24 Oct 2026· Journal of neuroimmunology· PUBMED
Publication
Activation of TLR4 promotes oxidative inflammation via NADPH oxidase signaling in platelets of subjects with autism spectrum disorder.
21 Oct 2026· Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society· PUBMED
Publication
Hesperidin-mediated selenium nanoparticles protect against diabetic cisplatin-induced testicular injury via modulation of Nrf2/Keap1, TLR4/NF-κB/MAPK, and PERK/CHOP Signaling.
19 Oct 2026· Tissue & cell· PUBMED
Publication
Mincle exacerbates neuroinflammation and dopaminergic neurodegeneration via synergistic crosstalk with TLR4.
18 Oct 2026· International immunopharmacology· PUBMED
Publication
Association of Intestinal Barrier Damage and Mucosal Microbiota Dysbiosis with the TLR4/NF-κB Pathway in High-Salt Diet-Induced Hypertensive Rats.
17 Oct 2026· Nutrients· PUBMED
Publication
Exertional heat stroke induces liver injury through the activation of the TLR4/NF-κB signaling pathway.
17 Oct 2026· Biochemistry and biophysics reports· PUBMED
Publication
Yixintai granules enhance glucose and lipid metabolism after ischemic heart failure by regulating inflammatory factors via the LPS/TLR4/NF-κB signaling pathway.
16 Oct 2026· Frontiers in immunology· PUBMED
Publication
Targeting TLR4 alleviates the progression of experimental autoimmune encephalomyelitis by regulating central resident cells and Th1/Th17 cell differentiation.
16 Oct 2026· Frontiers in immunology· PUBMED
Publication
Reversal of T1D and Rapid Reduction of β-Cell Stress by IL-10-Dependent MDSCs Induced by TLR4-Ab.
15 Oct 2026· Diabetes· PUBMED
Publication
Tetrachloro-1,4-benzoquinone Exerts Neurotoxicity through Neuroinflammation and the TLR4 Signaling Pathway, which is a Risk Factor for Alzheimer's Disease: An Integrated Network and Mendelian Randomization Analysis.
9 Oct 2026· Current Alzheimer research· PUBMED
Publication
Tauroursodeoxycholic acid ameliorates DSS-induced ulcerative colitis via regulating TLR4/NLRP3/pyroptosis axis and Keap1/Nrf2 pathway and restoring gut barrier function.
9 Oct 2026· European journal of pharmacology· PUBMED
Publication
Old Drugs, New Targets: Molecular Docking Insights into Repurposing Proton Pump Inhibitors for the TLR4/MD-2, NLRP3, and C5aR1 Axes in Autoimmune Liver Diseases.
6 Oct 2026· Pharmaceuticals (Basel, Switzerland)· PUBMED
Publication
Ferulic acid-mediated selenium nanoparticles attenuate oxaliplatin-induced renal injury in type 2 diabetic rats via modulation of oxidative stress, SIRT1/HMGB1/TLR4 signaling, endoplasmic reticulum stress, and apoptosis.
4 Oct 2026· Tissue & cell· PUBMED
Publication
Protocatechualdehyde ameliorates temporal lobe epilepsy via synergistic regulation of HMGB1-TLR4-NF-κB pathway and metabolic reprogramming.
1 Oct 2026· Journal of ethnopharmacology· PUBMED
Publication
Moghat, the roots of Glossostemon bruguieri (Desf.) as a nutraceutical against metabolic syndrome through PI3K/AKT/mTOR and TLR4-MYD88-p38 MAPK pathways.
1 Oct 2026· The Journal of pharmacy and pharmacology· PUBMED
Publication
Emerging links between TLR4 signaling and ferroptosis in heart failure.
1 Oct 2026· Frontiers in pharmacology· PUBMED
Publication
Shenghui Decoction ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via modulation of the HMGB1/TLR4/NLRP3 pathway.
24 Sept 2026· Journal of ethnopharmacology· PUBMED
Publication
Compound Kushen Injection Alleviates Experimental Colitis in Mice by Regulating Macrophage Polarization through TLR4/NF-κB Signaling.
22 Sept 2026· Chinese journal of integrative medicine· PUBMED
Publication
Scutellarin attenuates high glucose-induced edema and inflammation in retinal Müller cells via AQP4/Kir4.1 restoration and TLR4/MyD88/NF-κB inhibition.
18 Sept 2026· Frontiers in pharmacology· PUBMED
Publication
Expression and Localization of AKT1, MAPK13, STAT1 and TLR4 in Lung Tissues From Patients With Asthma, COPD and Asthma-COPD Overlap.
17 Sept 2026· Archivos de bronconeumologia· PUBMED
Publication
Qijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB pathway.
16 Sept 2026· Frontiers in microbiology· PUBMED
Publication
Therapeutic Potential of Berberine in Obesity-Associated Neuroinflammation Through Shared Molecular Pathways: TLR4/NF-κB/MAPK, ROS/NRF2 and NLRP3.
14 Sept 2026· Nutrients· PUBMED
Publication
Melatonin exerts an in vitro anti-glioblastoma effect through SIRT1-mediated HMGB1 deacetylation and inhibition of the TLR4/NF-κB pathway.
14 Sept 2026· Oncology letters· PUBMED
Publication
Targeting TLR4/NF-κB/NLRP3 signaling with 6-hydroxyflavanone mitigates amyloid-β-induced Alzheimer's disease in mice.
12 Sept 2026· Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie· PUBMED
Preprint
Tumor-derived SAA1-TLR4 signaling drives tumor-to-muscle communication in pancreatic cancer cachexia.
9 Sept 2026· bioRxiv : the preprint server for biology· PUBMED