Target

TREM2

Triggering receptor expressed on myeloid cells 2

0open trials
0trials in total
162publications
0researchers

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

Publication
Tumor-derived amyloid-β drives TREM2+ macrophages immunosuppression in cholangiocarcinoma.
29 Oct 2026· International immunopharmacology· PUBMED
Publication
A small-molecule TREM2 agonist for Alzheimer's disease.
29 Oct 2026· Nature medicine· PUBMED
Preprint
Genetic drivers shape TREM2-dependent myeloid responses and glioblastoma progression.
27 Oct 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
TREM2: friend or foe in glioma?
27 Oct 2026· Brain : a journal of neurology· PUBMED
Publication
TREM2/IGF-1 signaling axis-induced microglial senescence underlies benzo[a]pyrene-associated Parkinson's disease-like lesions.
26 Oct 2026· Chemico-biological interactions· PUBMED
Publication
TREM2 Signaling and Alzheimer's Disease: Experimental Modulators, Progress, and Challenges.
23 Oct 2026· Drug design, development and therapy· PUBMED
Publication
Erratum for the Research Article "Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer's disease".
21 Oct 2026· Science translational medicine· PUBMED
Publication
TREM2 deficiency attenuates endometriosis progression by inhibiting M2 polarization of SpMs and suppressing SIRPα to enhance phagocytosis†.
15 Oct 2026· Biology of reproduction· PUBMED
Publication
Cancer Hacks Neurodegeneration: Cystatin-C as a Bridge for Microglial Amyloid Clearance via TREM2.
14 Oct 2026· Research (Washington, D.C.)· PUBMED
Publication
Preclinical and first-in-human evaluation of VG-3927/SAR448851, an oral small-molecule TREM2 agonist for Alzheimer's disease.
14 Oct 2026· Science translational medicine· PUBMED
Publication
SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC-derived model.
14 Oct 2026· The FEBS journal· PUBMED
Publication
Targeting TREM2+ and TIMD4+ Macrophages Reprograms the Tumor Microenvironment and Enhances PD-1 Blockade Efficacy in Intrahepatic Cholangiocarcinoma.
9 Oct 2026· Cancer communications (London, England)· PUBMED
Publication
XL-MS and De Novo Protein Design Identified a Common Motif for TREM2 Binding.
7 Oct 2026· ACS chemical neuroscience· PUBMED
Publication
TREM2+ macrophages mediate anticancer therapy-induced immune evasion in lung adenocarcinoma via the CCL5/CCL22-Treg axis.
6 Oct 2026· Frontiers in immunology· PUBMED
Publication
A MYC-LDHA-MCT4 expression program marks an SPP1/TREM2-centered macrophage state in pancreatic ductal adenocarcinoma.
5 Oct 2026· Frontiers in immunology· PUBMED
Publication
Correction: Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer.
1 Oct 2026· Journal of experimental & clinical cancer research : CR· PUBMED
Publication
Context-dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer.
1 Oct 2026· Clinical and translational medicine· PUBMED
Publication
Single-cell RNA sequencing reveals the interaction of TREM2+ macrophages and Tc17 lymphocytes in scalp psoriasis.
29 Sept 2026· Immunologic research· PUBMED
Publication
Activation of TREM2 via single-domain antibodies improves synaptic and cognitive function in 5×FAD mice.
26 Sept 2026· Cell reports· PUBMED
Publication
Identification of RNA-Binding Proteins Regulating the Alternative Splicing of TREM2 Exon 4.
25 Sept 2026· Genes· PUBMED
Publication
Dynamic Crosstalk Between TREM2+ Macrophages and the MASLD Hepatic Microenvironment.
24 Sept 2026· Biomedicines· PUBMED
Publication
Therapeutic Strategies Targeting TREM2 for Alzheimer's Disease: Current Advances and Future Perspectives.
22 Sept 2026· Current neuropharmacology· PUBMED
Preprint
A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer's disease.
20 Sept 2026· bioRxiv : the preprint server for biology· PUBMED
Publication
TREM2-directed therapy in Alzheimer's disease: from therapeutic window to clinical translation.
15 Sept 2026· Frontiers in aging neuroscience· PUBMED
Publication
Ionizing radiation induces bidirectional transcriptomic reprogramming and dynamic NOS2/TREM2 regulation in triple-negative breast cancer cells.
11 Sept 2026· International journal of radiation biology· PUBMED
Publication
S1P-TREM2 axis protects immunosuppressive neutrophils from ferroptosis to promote tumour progression in hepatocellular carcinoma.
7 Sept 2026· Gut· PUBMED
Publication
TMEM59 regulates microglial Aβ phagocytosis in a TREM2-dependent manner and acts as a potential therapeutic target for Aβ amyloidosis.
1 Sept 2026· Alzheimer's & dementia : the journal of the Alzheimer's Association· PUBMED
Publication
Heterogeneous Expression of TREM2 And STAB1 Among Tumor-Associated Macrophages in Clear-Cell Renal Cell Carcinoma.
29 Aug 2026· Acta histochemica et cytochemica· PUBMED
Publication
XPO1-mediated TRIM21 nuclear export reprograms TREM2+ macrophage polarization by targeting IRF3 to augment anti-PD-1 efficacy in small cell lung cancer.
22 Aug 2026· Nature communications· PUBMED
Publication
sAPPα acts as an endogenous ligand for TREM2 to regulate microglial survival and inflammatory responses in Alzheimer's disease.
20 Aug 2026· Neuroreport· PUBMED

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