YAP

Diseases

• Lung cancer2 trials
• Head and neck cancer1 trial
• Kidney cancer1 trial
• Mesothelioma1 trial

The last 24 months

New trials, publications, preprints and grants on this target, month by month.

TrialsPublicationsPreprintsGrants

• Publication

  [Clinicopathological study of YAP1-fusion positive supratentorial ependymoma].

  8 Nov 2026· Zhonghua bing li xue za zhi = Chinese journal of pathology· PUBMED

• Publication

  USP14 promotes malignant pleural mesothelioma progression and suppresses autophagy by stabilizing the YAP1-TEAD4 axis.

  4 Nov 2026· Molecular biology reports· PUBMED

• Publication

  FGFR1-driven brachyury promotes endothelial-like differentiation of glioblastoma stem cells via SOX2/ZEB1/YAP1 signaling pathways.

  3 Nov 2026· Cellular signalling· PUBMED

• Publication

  Reversal of acquired osimertinib resistance by YAP inhibition in lung cancer is associated with lipid metabolic reprogramming.

  2 Nov 2026· Toxicology and applied pharmacology· PUBMED

• Publication

  Allele-Specific GNAQ Q209 Mutations Reveal Context-Dependent Oncogenic Programs in Uveal Melanoma.

  1 Nov 2026· Pigment cell & melanoma research· PUBMED

• Publication

  Aloe-Emodin Attenuates Cisplatin-Induced Ferroptotic Osteogenic Impairment in Bone Marrow Stromal Cells Through a YAP1-Dependent Mechanism.

  30 Oct 2026· Drug design, development and therapy· PUBMED

• Publication

  Immunophenotyping of the molecular subtypes of small-cell lung cancer and its correlation with prognostic and therapeutic implications.

  29 Oct 2026· Journal of cancer research and therapeutics· PUBMED

• Publication

  The expression of the collagen chaperone Hsp47 is regulated by mechanical loading through the YAP/TEAD pathway.

  28 Oct 2026· The Journal of biological chemistry· PUBMED

• Publication

  Dihydroartemisinin suppresses YAP1/SP1-associated SLC6A6 expression to remodel taurine homeostasis and increase intratumoral CD8+T cells in hepatocellular carcinoma.

  26 Oct 2026· International immunopharmacology· PUBMED

• Publication

  MRAS, SHOC2, PP1C and YAP1 mRNA level variations at 72 hours of targeted therapy in KRAS G12C-mutant non-small cell lung cancer cell lines.

  24 Oct 2026· Annals of translational medicine· PUBMED

• Publication

  YAP inhibits vascular calcification by promoting Beclin1 ubiquitination and autophagy.

  23 Oct 2026· Tissue & cell· PUBMED

• Publication

  Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote immune evasion in head and neck squamous cell carcinoma.

  23 Oct 2026· Communications biology· PUBMED

• Publication

  Atorvastatin protects cardiomyocytes from doxorubicin toxicity by modulating YAP/TAZ signaling.

  21 Oct 2026· BMB reports· PUBMED

• Publication

  [Suanzaoren Decoction inhibits neuroinflammation and alleviates hippocampal neuronal injury in APP/PS1 transgenic mice by regulating the Hippo-YAP pathway].

  20 Oct 2026· Nan fang yi ke da xue xue bao = Journal of Southern Medical University· PUBMED

• Publication

  Zyxin protects against hypertensive nephropathy by restraining FAK/Skp2-CDK8/YAP signaling in tubular epithelial cells.

  17 Oct 2026· Inflammation research : official journal of the European Histamine Research Society ... [et al.]· PUBMED

• Publication

  FTO Promotes Osteosarcoma Progression via YAP and Reduces Cisplatin Sensitivity.

  15 Oct 2026· Frontiers in bioscience (Landmark edition)· PUBMED

• Publication

  VGLL4 Suppresses Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells Through Modulation of Hippo/YAP and Wnt/β-Catenin Signaling Pathways.

  14 Oct 2026· Biomedicines· PUBMED

• Publication

  Targeting YAP/TEAD signaling disturbs RNA Pol II activity and enhances immunotherapy response via activated cytosolic DNA sensing pathway in gastroesophageal cancer.

  8 Oct 2026· Molecular cancer therapeutics· PUBMED

• Publication

  YAP and WWTR1/TAZ Connect Mechanotransduction and Mitochondrial Metabolism in Cardiac Hypertrophy and Ventricular Remodeling.

  8 Oct 2026· Journal of cardiovascular translational research· PUBMED

• Publication

  Hippo-YAP signaling: A novel pathway regulating platelet activation and thrombogenesis.

  7 Oct 2026· Life sciences· PUBMED

• Publication

  Lactate-induced MBD2 K186 lactylation promotes YAP1-dependent myofibroblast-like remodeling of Müller cells in diabetic retinopathy.

  6 Oct 2026· Molecular biomedicine· PUBMED

• Publication

  RhoA Y42C drives cell plasticity and PD-1-mediated immune evasion of diffuse gastric cancer.

  6 Oct 2026· Nature communications· PUBMED

• Publication

  Synthetic lethal screens reveal p300/CBP as a vulnerability for GNAQ-driven uveal melanomas.

  2 Oct 2026· Nature communications· PUBMED

• Publication

  HMGA2 Stabilizes hnRNPK to Drive YAP-Dependent Liver Metastasis in Pancreatic Cancer.

  2 Oct 2026· International journal of biological sciences· PUBMED

• Publication

  The Noncanonical Role of Hippo Signaling in Cancer.

  1 Oct 2026· Cold Spring Harbor perspectives in biology· PUBMED

• Publication

  MicroRNA-driven regulation of immunosuppressive microenvironment in hepatocellular carcinoma.

  28 Sept 2026· Proceedings of the National Academy of Sciences of the United States of America· PUBMED

• Publication

  Sanguinarine ameliorates rheumatoid arthritis by activating the Hippo-YAP/TAZ pathway to induce apoptosis and suppress inflammation in fibroblast-like synoviocytes.

  28 Sept 2026· Frontiers in pharmacology· PUBMED

• Publication

  Tetracyclic pyrazinocarbazole derivatives as YAP-TEAD pathway inhibitors with activity in a melanoma lung colonization model.

  27 Sept 2026· Bioorganic chemistry· PUBMED

• Publication

  Down-regulation of RhoA inhibits YAP by activating Hippo signaling to promote macrophage M1 polarization and enhance its phagocytosis, thereby inhibiting AML progression in preclinical models.

  25 Sept 2026· Molecular and cellular probes· PUBMED

• Publication

  Ceramide synthesis mediates colorectal cancer metastasis through a YAP-driven regenerative program.

  24 Sept 2026· Science (New York, N.Y.)· PUBMED

Who works on it

Researchers who published on this target. Leave out your own co-author circle to find people you do not know yet.

No published researcher profile on this target yet.