2022-500779-29-00CompletedPhase 2
MORPHINE PHARMACOKINETICS AND –DYNAMICS IN HEALTHY VOLUNTEERS AND PATIENTS WITH OBESITY AND OBSTRUCTIVE SLEEP APNOEA. AN INVESTIGATOR INITIATED, CLINICAL STUDY OF THE IMPACT OF OBESITY AND SLEEP APNOEA ON THE PHARMACOLOGY OF MORPHINE
MORPHINE PHARMACOKINETICS AND –DYNAMICS IN HEALTHY VOLUNTEERS AND PATIENTS WITH OBESITY AND OBSTRUCTIVE SLEEP APNOEA. -AN INVESTIGATOR INITIATED, CLINICAL STUDY OF THE IMPACT OF OBESITY AND SLEEP APNOEA ON THE PHARMACOLOGY OF MORPHINE
Source: EU CTIS (euclinicaltrials.eu) · Last updated 16 Dec 2025
Brief summary (registry, in English)
It is expected that the trial will produce important knowledge on the safety and efficacy of morphine for perioperative pain, which will be beneficial for future surgical patients, in particular for bariatric patients suffering from obstructive sleep apnoea subjected to bariatric surgery. Furthermore, we aim to gain from new insights and understanding of the pharmacokinetics and pharmacodynamics of morphine – which to this day is a first line drug when acute pain-relief is needed. We aim to further our knowledge and understanding of a more personalized approach to the treatment of acute peri- and postoperative pain, i.e. delivering sufficient pain-relief with an absolute minimum of side effects.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 140 (actual)
- First submitted
- 23 Jun 2022
- Start date
- 1 Dec 2022
- Lead sponsor
- Sydvestjysk Sygehus
- Diseases
- Obesity
- EU CT number
- 2022-500779-29-00
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 140
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known allergy towards morphine
- Severe heart failure
- History of substance abuse
- History of mayor psychiatric illness
- Severe acute respiratory affection, i.e. airway infections
- Known history of severe chronic pain
Other
- Female participants that are breastfeeding
- Intake of alcohol within 24 hours before start of the trial
- Inability to present a negative pregnancy test
- Increased intracranial pressure
- Severe decreased renal or hepatic function
- Severe COPD or asthma
Who the study is looking for
- Obesity
- Obstructive sleep apnoea
Age in the registry: 18 years to 64 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sydvestjysk Sygehus | Esbjerg | Denmark | Completed |
This page is information, not medical advice. Discuss any trial with your doctor.