Under construction – not a live service
Sign in

2022-502040-13-00CompletedPhase 2

Magrolimab plus intensive chemotherapy in newly diagnosed “ELN intermediate or poor-risk” AML patients intended to undergo allogeneic stem cell transplantation, a Phase 2, Single-arm, Open-Label Study (MAGROLIC)

Source: EU CTIS (euclinicaltrials.eu) · Last updated 18 Jul 2023

Next steps

Brief summary (registry, in English)

Best CR/CRi/CRh during induction chemotherapy

Status (registry)
Completed
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
108 (actual)
First submitted
29 Mar 2023
Start date
2 Oct 2023
Lead sponsor
University of Leipzig
EU CT number
2022-502040-13-00

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 108
  • 22 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.

Who cannot take part

Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Not eligible for intensive chemotherapy
  • Any prior treatment for AML or high-risk MDS (including magrolimab) except hydoxyurea

Other illness

  • Inadequate cardiac, pulmonary, renal, hepatic function
  • Active and uncontrolled infection
  • Diagnosed or treated for another malignancy within 1 year before registration

Other

  • Harboring a FLT3mut, regardless of FLT3-ITD or FLT3-TKD mutation status
  • Acute promyelocytic leukemia (APL)
  • ECOG ≥3

Who the study is looking for

  • AML or MDS-IB-2 according to WHO 2022 criteria
  • “Intermediate or adverse risk” ELN 2022 category (for both MDS or AML)
  • Intention to undergo intensive chemotherapy (CPX-351 or “7+3”) followed by allogeneic HSCT

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on EU CTIS (euclinicaltrials.eu)

Sites (22)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Universitaetsklinikum Aachen AöRAachenGermanyCompleted
University Hospital AugsburgAugsburgGermanyCompleted
Sozialstiftung BambergBambergGermanyCompleted
HELIOS Klinikum Berlin Buch GmbHBerlinGermanyCompleted
Klinikum Chemnitz gGmbHChemnitzGermanyCompleted
Carl Thiem Klinikum gGmbHCottbusGermanyCompleted
Technische Universität DresdenDresdenGermanyCompleted
HELIOS Klinikum Duisburg GmbHDuisburgGermanyCompleted
Universitaetsklinikum Erlangen AöRErlangenGermanyCompleted
Goethe University FrankfurtFrankfurt Am MainGermanyCompleted
Martin-Luther-Universitaet Halle-WittenbergHalle (Saale)GermanyCompleted
Universitaetsklinikum Heidelberg AöRHeidelbergGermanyCompleted
University Hospital Jena KöRJenaGermanyCompleted
University Medical Centre Schleswig-HolsteinKielGermanyCompleted
Gemeinschaftsklinikum Mittelrhein gGmbHKoblenzGermanyCompleted
Universitaet LeipzigLeipzigGermanyCompleted
Universitaetsklinikum Mannheim GmbHMannheimGermanyCompleted
Westfaelische Wilhelms-Universitaet MuensterMuensterGermanyCompleted
Barmherzige Brueder gemeinnuetzige Krankenhaus GmbHRegensburgGermanyCompleted
Elblandkliniken Stiftung & Co.KGRiesaGermanyCompleted
Kliniken SindelfingenSindelfingenGermanyCompleted
Robert Bosch Gesellschaft fuer medizinische Forschung mbHStuttgartGermanyCompleted

Are you the coordinator? Confirm the details

This page is information, not medical advice. Discuss any trial with your doctor.