2023-504519-34-01CompletedPhase 2
Using live vaccines to induce beneficial innate immune training and reduce systemic inflammation in COPD patients
Using live vaccines to induce beneficial innate immune training and reduce systemic inflammation in COPD patients (COPD-LIVE)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 23 Apr 2024
Brief summary (registry, in English)
To characterize the changes in the innate immune system of COPD patients upon vaccination with live vaccines and determine if vaccination induces trained immunity as reported previously in other populations.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 18 Oct 2023
- Start date
- 22 Feb 2024
- Lead sponsor
- Gentofte Hospital
- Diseases
- COPD
- EU CT number
- 2023-504519-34-01
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 60
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Oral or intravenous corticosteroid at a dose ≥10 mg/day over 3 months
- Known allergy to either the BCG or MMR vaccines or severe adverse effects during prior vaccination.
- Known prior, active or latent infection with mycobacterium tuberculosis.
- Vaccination with a live vaccine within 4 weeks
Other illness
- Cardiac arythmia
- Allergy to MMR vaccine components, neomycin or egg proteins.
- Severe immunocompromisation (HIV-1 infection, organ- or bone marrow transplantation, chemotherapy, primary immune defect, anti-cytokine therapy, immunosuppressant treatment).
- Active solid or non-solid malignancy or lymphona within 2 years, excluding basal cell carcinoma
Other
- Acute febrile ilness
- Blood dyscrasia
- Pregnancy or breastfeeding
Who the study is looking for
- Must have specialist verified, spirometry-confirmed, COPD.
- Age > 40 years
- Able to give informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Gentofte Hospital | Hellerup | Denmark | Completed |
This page is information, not medical advice. Discuss any trial with your doctor.