2023-505121-14-00RecruitingPhase 3
A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled and Deucravacitinib Active Comparator-controlled Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis
Source: EU CTIS (euclinicaltrials.eu) · Last updated 16 Jul 2026
Brief summary (registry, in English)
To evaluate the efficacy of JNJ-77242113 compared with placebo in participants with moderate to severe plaque psoriasis.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 320 (estimated)
- First submitted
- 11 Sept 2023
- Start date
- 18 Jan 2024
- Lead sponsor
- Janssen - Cilag International
- Diseases
- Psoriasis
- EU CT number
- 2023-505121-14-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 320
- 63 sites in 6 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
AI-kivonat: who the study is looking for
Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with moderate to severe plaque psoriasis. It tests JNJ-77242113 against a placebo and against deucravacitinib.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Plaque psoriasis, with or without psoriatic arthritis (PsA), diagnosed at least 26 weeks before the first study treatment. Skin area affected (BSA) 10% or more, PASI score 12 or more, and IGA score 3 or more, at screening and at baseline.
Main reasons for not taking part
- A form of psoriasis that is not plaque psoriasis
- Psoriasis caused by a drug right now
- Severe, worsening or uncontrolled kidney, liver, heart, blood vessel, lung, stomach and bowel, hormone, nerve, blood, rheumatic, mental health or metabolic problems
- Known allergy or intolerance to JNJ-77242113, deucravacitinib or any ingredient of the study treatment
- Major surgery within 8 weeks before screening, not fully recovered, or planned during the trial
Read by machine on 9 Nov 2026.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current drug-induced psoriasis.
- Major surgical procedure, within 8 weeks before screening, or will not have fully recovered from surgical procedure, or has a surgical procedure planned during the time the participant is expected to participate in the study.
Other illness
- A current diagnosis or signs or symptoms of severe, progressive, or uncontrolled renal, liver, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances.
- Known allergies, hypersensitivity, or intolerance to JNJ-77242113, deucravacitinib, or to any of the excipients or components of the study intervention.
Other
- Nonplaque form of psoriasis.
Who the study is looking for
- ≥18 years of age at the screening visit.
- Diagnosis of plaque psoriasis, with or without PsA, for at least 26 weeks prior to the first administration of study intervention.
- Total BSA ≥10% at screening and baseline.
- Total PASI ≥12 at screening and baseline.
- Total IGA ≥3 at screening and baseline.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (63)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| ISA - Interdisciplinary Study Association GmbH | Berlin | Germany | Active, not recruiting |
| Studienzentrum an der Hase Weyergraf/Frick/Heiber | Bramsche | Germany | Active, not recruiting |
| Klinische Forschung Dresden GmbH | Dresden | Germany | Active, not recruiting |
| Praxis fuer Dermatologie und Venerologie | Dresden | Germany | Active, not recruiting |
| Universitaetsklinikum Duesseldorf AöR | Duesseldorf | Germany | Active, not recruiting |
| MENSINGDERMAresearch GmbH | Hamburg | Germany | Active, not recruiting |
| University Medical Center Hamburg-Eppendorf | Hamburg | Germany | Active, not recruiting |
| Universitaetsklinikum Schleswig-Holstein | Kiel | Germany | Active, not recruiting |
| Studienzentrum Dr. Schwarz | Langenau | Germany | Active, not recruiting |
| Universitaet Leipzig | Leipzig | Germany | Active, not recruiting |
| Universitaetsklinikum Schleswig-Holstein | Lübeck | Germany | Active, not recruiting |
| Universitaetsklinikum Mannheim GmbH | Mannheim | Germany | Active, not recruiting |
| Klinikum rechts der Isar der TU Muenchen AöR | Munich | Germany | Active, not recruiting |
| MVZ Corius Potsdam GmbH | Potsdam | Germany | Active, not recruiting |
| Rostock University Medical Center | Rostock | Germany | Active, not recruiting |
| Hospital General Universitario Dr. Balmis | Alicante | Spain | Active, not recruiting |
| Hospital Universitario de Cruces | Barakaldo | Spain | Active, not recruiting |
| Hospital de la Santa Creu i Sant Pau | Barcelona | Spain | Active, not recruiting |
| Hospital Universitario Clínico San Cecilio | Granada | Spain | Active, not recruiting |
| Bellvitge University Hospital | L'hospitalet De Llobregat | Spain | Active, not recruiting |
| Hospital General Universitario Gregorio Marañón | Madrid | Spain | Active, not recruiting |
| Hospital Universitario 12 de Octubre | Madrid | Spain | Active, not recruiting |
| Hospital Universitario de la Princesa | Madrid | Spain | Active, not recruiting |
| Hospital Universitario La Paz | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Infanta Leonor | Madrid | Spain | Active, not recruiting |
| Icr Medical S.L. | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Y Politecnico La Fe | Valencia | Spain | Active, not recruiting |
| Hopital Prive D Antony | Antony | France | Withdrawn |
| Centre Hospitalier Universitaire Grenoble Alpes | Grenoble Cedex 9 | France | Withdrawn |
| Hospital Hotel Dieu | Nantes | France | Withdrawn |
| Assistance Publique Hopitaux de Paris | Paris | France | Withdrawn |
| Centre Hospitalier Annecy Genevois | Pringy Cedex | France | Withdrawn |
| CHU De Rouen | Rouen Cedex | France | Withdrawn |
| Centre Hospitalier Universitaire de Toulouse | Toulouse | France | Withdrawn |
| Obudai Egeszsegugyi Centrum Kft. | Budapest III | Hungary | Active, not recruiting |
| Derma-B Kft. | Debrecen | Hungary | Active, not recruiting |
| University of Debrecen | Debrecen | Hungary | Active, not recruiting |
| Somogy Vármegyei Kaposi Mór Oktató Kórház | Kaposvár | Hungary | Active, not recruiting |
| University of Pecs | Pécs | Hungary | Active, not recruiting |
| University of Szeged | Szeged | Hungary | Active, not recruiting |
| Allergo-Derm Bakos Kft | Szolnok | Hungary | Active, not recruiting |
| Medmare Bt. | Veszprém | Hungary | Active, not recruiting |
| Presidio Ospedaliero San Giovanni Di Dio | Cagliari | Italy | Withdrawn |
| University Hospital Of Ferrara | Ferrara | Italy | Withdrawn |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico | Milan | Italy | Withdrawn |
| Azienda Ospedaliera Universitaria Federico II Di Napoli | Naples | Italy | Withdrawn |
| Azienda Ospedaliero Universitaria Maggiore della Carità | Novara | Italy | Withdrawn |
| Specderm Poznanska sp.j. | Bialystok | Poland | Active, not recruiting |
| Osteo Medic s.c. Artur Racewicz Jerzy Supronik | Bialystok | Poland | Active, not recruiting |
| Promed P.Lach R.Glowacki Sp. j. | Cracow | Poland | Active, not recruiting |
| Centrum Medyczne Dr Rajzer Sp. z o.o. | Cracow | Poland | Active, not recruiting |
| Centrum Kliniczno-Badawcze J.Brzezicki B.Gornikiewicz-Brzezicka Lekarze sp.p. | Elblag | Poland | Active, not recruiting |
| Specjalistyczny Gabinet Dermatologiczny Aplikacyjno Badawczy Marek Brzewski Paweł Brzewski s.c. | Krakow | Poland | Active, not recruiting |
| Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A. | Lodz | Poland | Active, not recruiting |
| DERMED Centrum Medyczne Sp. z o.o. | Lodz | Poland | Active, not recruiting |
| DermoDent Centrum Medyczne Aldona Czajkowska Rafal Czajkowski s.c | Osielsko (Bydgoszcz) | Poland | Active, not recruiting |
| Solumed Centrum Medyczne Sp. z o.o. | Poznan | Poland | Active, not recruiting |
| Clinical Research Center Sp z o o Medic R Sp k | Poznan | Poland | Active, not recruiting |
| Dorota Bystrzanowska High-Med. Przychodnia Specjalistyczna | Warsaw | Poland | Active, not recruiting |
| Klinika Ambroziak Sp. z o.o. | Warsaw | Poland | Active, not recruiting |
| Centrum Medyczne Oporow | Wroclaw | Poland | Active, not recruiting |
| dermMedica Sp. z o.o | Wroclaw | Poland | Active, not recruiting |
| WroMedica I Bielicka A Strzalkowska s c | Wroclaw | Poland | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.