MK-7480 Single Ascending Dose Study in Healthy Participants

Prior treatment

• A regular user of cannabis, any illicit drugs or has a history of drug (including alcohol) abuse within approximately 12 months. Participants must have a negative drug screen prior to randomization
• The participant had a major surgery and/or donated or lost 1 unit of blood (approximately 500 mL) within 4 weeks prior to the prestudy (screening) visit
• Has received any nonlive vaccine starting from 14 days prior to study intervention or is scheduled to receive any nonlive vaccine through 30 days following study intervention. Exception: COVID-19 or inactivated influenza vaccines may be administered. Study intervention must be given at least 72 hours following or at least 48 hours prior to any COVID-19 or influenza vaccination.
• Unable to refrain from or anticipates the use of any medication, including prescription and nonprescription drugs or herbal remedies beginning approximately 4 weeks prior to administration of the initial dose of study intervention, throughout the study (including washout intervals between treatment periods), until the poststudy visit

Other illness

• History of clinically significant endocrine, GI, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases
• History of cancer (malignancy)
• Positive test(s) for hepatitis B surface antigen (HBsAg), hepatitis C antibodies or HIV

Other

• Consumes excessive amounts, defined as greater than 6 servings (1 serving is approximately equivalent to 120 mg of caffeine) of coffee, tea, cola, energy drinks, or other caffeinated beverages per day
• Participated in another investigational study within 4 weeks
• The participant is a smoker and/or has used nicotine or nicotine-containing products (e.g., nicotine patch and electronic cigarette) within 3 months
• Consumes greater than 3 servings of alcoholic beverages (1 serving is approximately equivalent to: beer [354 mL/12 ounces], wine [118 mL/4 ounces], or distilled spirits [29.5 mL/1 ounce]) per day

• Be in good health
• Body Mass Index (BMI) of 18-32 kg/m2
• Assigned male sex at birth
• Abstains from penile-vaginal intercourse as their preferred and usual lifestyle (abstinent on a long-term and persistent basis) and agrees to remain abstinent or uses a protocol-defined method of contraception
• Willing to comply with the study restrictions