2023-505940-20-00RecruitingPhase 4
The OPTIMIST study
The Optimised use of Romosozumab Study
Source: EU CTIS (euclinicaltrials.eu) · Last updated 5 Oct 2026
Brief summary (registry, in English)
The main objective of the OPTIMIST study is to identify the optimal use of romosozumab for the treatment of osteoporosis by investigating 3 different treatment strategies.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 270 (estimated)
- First submitted
- 24 May 2023
- Start date
- 26 Sept 2023
- Lead sponsor
- Aarhus University Hospital
- Diseases
- Osteoporosis
- EU CT number
- 2023-505940-20-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 270
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Ongoing treatment with glucocorticoids
Other illness
- Metabolic bone disease
- Known disorders affecting bone metabolism
Lab values
- Estimated glomerular filtration rate (eGFR) < 35 ml/min
Other
- Osteoporosis treatment within the last 5 years
- Contraindications or intolerance to romosozumab or zoledronate
Who the study is looking for
- postmenopausal women
- Osteoporosis defined as BMD T-score < -2.5 at spine, total hip or femoral neck
- Osteoporotic fracture at spine, hip, pelvis, forearm, or humerus within 3 years after the age of 50 years
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aalborg University Hospital | Aalborg | Denmark | Recruiting |
| Aarhus Universitetshospital | Aarhus N | Denmark | Recruiting |
| Bispebjerg Hospital | Copenhagen Nv | Denmark | Recruiting |
| Hvidovre Hospital | Hvidovre | Denmark | Recruiting |
| Odense University Hospital | Odense C | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.