2023-506185-31-00CompletedPhase 2/3

A randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of PLN-74809 (bexotegrast) for the treatment of idiopathic pulmonary fibrosis (BEACON-IPF)

Source: EU CTIS (euclinicaltrials.eu) · Last updated 6 Mar 2025

Brief summary (registry, in English)

To characterize the effect of bexotegrast versus placebo on the change in force vital capacity FVC in participants with idiopathic pulmonary fibrosis (IPF) at Week 52

Status (registry): Completed
Phase (registry): Phase 2/3
Study type: Interventional
Enrollment: 318 (actual)
First submitted: 27 Oct 2023
Start date: 18 Jul 2024
Lead sponsor: Pliant Therapeutics Inc.
Diseases: Idiopathic pulmonary fibrosis
EU CT number: 2023-506185-31-00

What you commit to

Study type: Interventional · Phase 2/3
Participants enrolled: 318
79 sites in 11 countries
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.

Who cannot take part

Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.

Prior treatment

Receiving pharmacologic therapy for pulmonary hypertension

Other

Forced expiratory volume in the first second/FVC ratio <0.7 at Screening (as confirmed with central review)

Who the study is looking for

≥ 40 years of age prior to screening
IPF diagnosis ≤7 years prior to screening based upon American Thoracic Society / European Respiratory Society / Japanese Respiratory Society / Latin American Thoracic Association 2018 guidelines and confirmed with central review (Raghu et al 2018). An HRCT scan performed ≤ 2 years prior to screening may be used for eligibility.
FVCpp ≥45% confirmed with central review
Diffusing capacity for carbon monoxide percent predicted (hemoglobin-adjusted) ≥30% and <90% confirmed with central review
Current treatment for IPF with background therapy is allowed, if at a stable dose for ≥ 12 weeks prior to screening

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on EU CTIS (euclinicaltrials.eu)

Sites (79)

Sites in registry order. Save your city in your profile to sort them by distance.

Site	City	Country	Site status
UZ Leuven	Leuven	Belgium	Completed
CHU de Liège	Liège	Belgium	Completed
Algemeen Ziekenhuis Delta	Roeselare	Belgium	Completed
Fakultni nemocnice Brno	Brno	Czechia	Completed
University Hospital Olomouc	Olomouc	Czechia	Completed
Fakultni Thomayerova nemocnice	Prague 4	Czechia	Completed
Zentralklinik Bad Berka GmbH	Bad Berka	Germany	Completed
Evangelische Lungenklinik Berlin Krankenhausbetriebs gGmbH	Berlin	Germany	Completed
Kliniken der Stadt Koeln gGmbH	Cologne	Germany	Completed
GWT-Tud GmbH	Coswig	Germany	Completed
Ruhrlandklinik Westdeutsches Lungenzentrum Am Universitaetsklinikum Essen gGmbH	Essen	Germany	Completed
IKF Pneumologie GmbH & Co. KG	Frankfurt am Main	Germany	Completed
Asklepios Klinik Gauting GmbH	Gauting	Germany	Completed
Justus-Liebig-Universitaet Giessen	Giessen	Germany	Completed
Universitaetsmedizin Greifswald KöR	Greifswald	Germany	Completed
Medizinische Hochschule Hannover	Hanover	Germany	Completed
Universitaet Des Saarlandes	Homburg	Germany	Completed
Universitaetsklinikum Schleswig-Holstein	Kiel	Germany	Completed
Universitaet Leipzig	Leipzig	Germany	Completed
Klinikum der Universitaet Muenchen AöR	Munich	Germany	Completed
Krankenhaus Bethanien gGmbH	Solingen	Germany	Completed
Aarhus Universitetshospital	Aarhus N	Denmark	Completed
Gentofte Hospital	Hellerup	Denmark	Completed
Odense University Hospital	Odense C	Denmark	Completed
Hospital Clinic de Barcelona	Barcelona	Spain	Completed
Giromed Institute S.L.P.	Barcelona	Spain	Completed
Bellvitge University Hospital	L'hospitalet De Llobregat	Spain	Completed
Hospital Clínico San Carlos	Madrid	Spain	Completed
Clinica Universidad de Navarra	Madrid	Spain	Completed
Hospital Universitario de la Princesa	Madrid	Spain	Completed
Hospital Universitario Puerta de Hierro de Majadahonda	Majadahonda	Spain	Completed
Hospital Universitario Virgen de la Victoria	Málaga	Spain	Completed
Hospital Quirónsalud Marbella	Marbella	Spain	Completed
Clínica Universidad de navarra	Pamplona	Spain	Completed
Complexo Hospitalario Universitario De Santiago	Santiago de Compostela	Spain	Completed
Hospital Alvaro Cunqueiro	Vigo	Spain	Completed
Assistance Publique Hopitaux De Paris	Bobigny	France	Completed
Hospices Civils de Lyon	Bron	France	Completed
Centre Hospitalier Universitaire de Lille	Lille	France	Completed
Assistance Publique Hôpitaux de Marseille	Marseille	France	Completed
Centre Hospitalier Universitaire De Montpellier	Montpellier Cedex 5	France	Completed
Centre Hospitalier Universitaire de Nice	Nice	France	Completed
Assistance Publique Hopitaux De Paris	Paris Cedex 18	France	Completed
Centre Hospitalier Universitaire de Bordeaux	Pessac	France	Completed
Centre Hospitalier Universitaire Reims	Reims	France	Completed
Centre Hospitalier Universitaire de Rennes	Rennes	France	Completed
Centre Hospitalier Universitaire de Toulouse	Toulouse	France	Completed
Centre Hospitalier Régional Universitaire de Tours	Tours	France	Completed
University General Hospital of Alexandroupoli	Alexandroupoli	Greece	Completed
Thoracic General Hospital of Athens "I Sotiria"	Athens	Greece	Completed
University General Hospital of Heraklion	Heraklion	Greece	Completed
University General Hospital of Ioannina	Ioannina	Greece	Completed
General University Hospital of Larissa	Larissa	Greece	Completed
General University Hospital Of Patras	Patras	Greece	Completed
Geniko Nosokomeio Thessalonikis George Papanikolaou	Thessaloniki	Greece	Completed
Azienda Ospedaliero-Universitaria Ss Antonio E Biagio E Cesare Arrigo	Alexandria	Italy	Completed
Azienda Ospedaliera Papa Giovanni XXIII	Bergamo	Italy	Completed
Careggi University Hospital	Florence	Italy	Completed
Azienda Ospedaliero Universitaria Ospedali Riuniti	Foggia	Italy	Completed
Multimedica S.p.A.	Milan	Italy	Completed
Azienda Ospedaliero - Universitaria di Modena	Modena	Italy	Completed
Fondazione IRCCS San Gerardo dei Tintori	Monza	Italy	Completed
Fondazione Policlinico Universitario Agostino Gemelli IRCCS	Rome	Italy	Completed
Azienda Ospedaliera Universitaria Senese	Siena	Italy	Completed
Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino	Turin	Italy	Completed
Amsterdam UMC	Amsterdam	Netherlands	Completed
Zuyderland Medisch Centrum Stichting	Heerlen	Netherlands	Completed
St. Antonius Ziekenhuis	Nieuwegein	Netherlands	Completed
Medicover Integrated Clinical Services Sp. z o.o.	Bydgoszcz	Poland	Completed
Vitamed Galaj i Cichomski sp.j.	Bydgoszcz	Poland	Completed
Uniwersyteckie Centrum Kliniczne	Gdansk	Poland	Completed
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie	Krakow	Poland	Completed
IP Clinic Sp. z o.o.	Lodz	Poland	Completed
Zanamed Medical Clinic Sp. z o.o.	Lublin	Poland	Completed
Twoja Przychodnia Nowosolskie Centrum Medyczne Sp. z o.o.	Nowa Sol	Poland	Completed
CCAB Centro Clinico Academico Braga Associacao	Braga	Portugal	Completed
Unidade Local De Saude De Sao Jose E.P.E.	Lisbon	Portugal	Completed
Hospital Pedro Hispano	Matosinhos	Portugal	Completed
Unidade Local de Saúde de Gaia/Espinho, E. P. E	Vila Nova de Gaia	Portugal	Completed

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