2023-506310-43-00CompletedPhase 1
A Study to Evaluate Safety, Pharmacokinetics, and Preliminary Clinical Activity of RO7276389 Alone and in Combination with Cobimetinib in Participants with BRAF-V600 Mutation-Positive Advanced Solid Tumor or BRAF-V600 Mutation-Positive Melanoma with Central Nervous System Metastases
Source: EU CTIS (euclinicaltrials.eu) · Last updated 5 Dec 2025
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 70 (actual)
- First submitted
- 20 Dec 2023
- Start date
- 15 Feb 2022
- Lead sponsor
- F. Hoffmann-La Roche AG
- Diseases
- Melanoma
- EU CT number
- 2023-506310-43-00
- EudraCT number
- 2021-003426-77
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 70
- 11 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Sites (11)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Antwerp University Hospital | Edegem | Belgium | Completed |
| UZ Brussel | Jette | Belgium | Completed |
| UZ Leuven | Leuven | Belgium | Completed |
| Herlev Hospital | Herlev | Denmark | Completed |
| Vall D'hebron Institut De Recerca | Barcelona | Spain | Completed |
| Hospital Universitario HM Sanchinarro | Madrid | Spain | Completed |
| Clinica Universidad de Navarra | Madrid | Spain | Completed |
| Clínica Universidad de navarra | Pamplona | Spain | Completed |
| Uniwersyteckie Centrum Kliniczne | Gdansk | Poland | Completed |
| Uniwersytecki Szpital Kliniczny w Poznaniu | Poznan | Poland | Completed |
| Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy | Warsaw | Poland | Completed |
This page is information, not medical advice. Discuss any trial with your doctor.