DAPHNE

Prior treatment

• Contraindications for ixekizumab. • Contraindication for MRI. • Previous exposure to ixekizumab or other biologic drug directly targeting IL-17 or IL-17 receptor • Has received more than 1 prior anti-TNF inhibitor • Previous exposure to other types of bDMARDs than TNF inhibitor. • Active inflammatory bowel disease • DMARDs are allowed during the study, but the dose cannot be changed from 1 month before the first MRI. • Use of any investigational drug and/or devices within 1 month before randomization or a period of 5 half-lives of the investigational drug, whichever is longer. • Any use of oral, intravenous, intra-articular, or intra-muscular corticosteroids within 1 month before the baseline MRI. • Pregnant or nursing (lactating) women. • Known recent drug or alcohol abuse. • Known severe psychiatric disease. • Incapable of complying with the examination program for physical or mental reasons. • Unable to speak, read, or understand Danish.