2024-513092-40-00RecruitingPhase 4
Stopping or continuing blood thinners after stroke at young age without a known cause: STOP trial
Stopping or continuing platelet inhibitors after cryptogenic stroke at young age: STOP trial
Source: EU CTIS (euclinicaltrials.eu) · Last updated 21 Oct 2026
Brief summary (registry, in English)
To investigate whether discontinuation of antiplatelet therapy is non-inferior to continuation of antiplatelet therapy, to prevent major cardiovascular events three to ten years after cryptogenic TIA or ischaemic stroke at young age.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 1566 (estimated)
- First submitted
- 9 Jul 2024
- Start date
- 5 Dec 2024
- Lead sponsor
- Stichting Radboud universitair medisch centrum
- Diseases
- Stroke
- EU CT number
- 2024-513092-40-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 1566
- 41 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
AI-kivonat: who the study is looking for
Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who had a first stroke or mini-stroke at a young age with no known cause, 3 to 10 years ago. It tests stopping versus continuing blood thinners.
- Age
- 18-49 years at the time of the stroke or mini-stroke (the registry lists 18 to 64 years).
- Sex
- All sexes can join.
- Disease stage
- First ever ischaemic stroke, or TIA (mini-stroke) with signs of ischaemia on imaging, 3-10 years ago, with no cause found after standard tests (cryptogenic).
Main reasons for not taking part
- Heart attack, coronary revascularisation or peripheral artery disease in the past
- Another reason to take antiplatelet drugs, oral anticoagulants or low molecular weight heparin
- Another ischaemic event after the first stroke
- Any narrowing of an artery in the head or neck at the time of the stroke
- Two or more risk factors for atherosclerotic disease, or any condition that prevents long-term follow-up
Read by machine on 9 Nov 2026.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Other indication for antiplatelet therapy
Other illness
- History of MI, coronary revascularisation or documented peripheral arterial disease
- Any stenosis of intracranial or cervical artery at time of stroke
- Any condition that prevents long-term follow-up
Lab values
- Two or more risk factors for atherosclerotic disease according to the following definitions: • arterial hypertension (treated or known blood pressure before stroke >140/90 mm Hg) • diabetes mellitus (treated or known blood fasting glucose >7 mmol/l) • current smoking (or smoking stopped within the last 6 months), • hypercholesterolaemia (treated or known low-density lipoprotein before the stroke >160 mg/dl or 4, mmol/l)
Other
- Indication for oral anticoagulants or low molecular weight heparin
- Recurrent ischaemic event at any time after the index event
Who the study is looking for
- First ever ischaemic stroke, or TIA with evidence of ischaemia on imaging, 3-10 years prior to study participation
- Age 18-49 years at the time of TIA/ischaemic stroke
- Cryptogenic aetiology, defined as no other aetiology after standard work-up according to national and international guidelines for young stroke (imaging of the brain (CT-scan or MRI-scan) and cervical arteries (CTA, MRA or carotid ultrasound), routine blood tests (complete blood count, erythrocyte sedimentation rate, CRP, antiphospholipid antibodies), ECG, at least 24 hours cardiac rhythm monitoring and transthoracic/transesophageal echocardiography).
Age in the registry: 18 years to 64 years · Sex: All · Does not accept healthy volunteers
Sites (41)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Helsinki University Hospital | Helsinki | Finland | Not yet recruiting |
| Tampere University Hospital | Tampere | Finland | Not yet recruiting |
| Turku University Hospital | Turku | Finland | Not yet recruiting |
| University of Parma | Parma | Italy | Not yet recruiting |
| Noordwest Ziekenhuisgroep Stichting | Alkmaar | Netherlands | Recruiting |
| Flevoziekenhuis Stichting | Almere | Netherlands | Recruiting |
| Meander Medisch Centrum | Amersfoort | Netherlands | Recruiting |
| Academisch Medisch Centrum | Amsterdam | Netherlands | Recruiting |
| Stichting OLVG | Amsterdam | Netherlands | Recruiting |
| Gelre Hospitals | Apeldoorn | Netherlands | Recruiting |
| Rijnstate Ziekenhuis Stichting | Arnhem | Netherlands | Recruiting |
| Amphia Hospital | Breda | Netherlands | Recruiting |
| Reinier de Graaf Groep | Delft | Netherlands | Recruiting |
| Deventer Ziekenhuis | Deventer | Netherlands | Recruiting |
| Albert Schweitzer Ziekenhuis | Dordrecht | Netherlands | Recruiting |
| Catharina Ziekenhuis Stichting | Eindhoven | Netherlands | Recruiting |
| Medisch Spectrum Twente | Enschede | Netherlands | Recruiting |
| Universitair Medisch Centrum Groningen | Groningen | Netherlands | Recruiting |
| Spaarne Gasthuis Stichting | Haarlem | Netherlands | Recruiting |
| Zuyderland Medisch Centrum Stichting | Heerlen | Netherlands | Recruiting |
| Elkerliek ziekenhuis | Helmond | Netherlands | Recruiting |
| Medisch Centrum Leeuwarden B.V. | Leeuwarden | Netherlands | Recruiting |
| Leids Universitair Medisch Centrum (LUMC) | Leiden | Netherlands | Recruiting |
| Alrijne Zorggroep Stichting | Leiderdorp | Netherlands | Recruiting |
| Universiteit Maastricht | Maastricht | Netherlands | Recruiting |
| Sint Antonius Ziekenhuis Stichting | Nieuwegein | Netherlands | Recruiting |
| Radboud Universitair Medisch Centrum (Radboudumc) | Nijmegen | Netherlands | Recruiting |
| Canisius Wilhelmina Ziekenhuis | Nijmegen | Netherlands | Recruiting |
| Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) | Rotterdam | Netherlands | Recruiting |
| Maasstad Ziekenhuis Stichting | Rotterdam | Netherlands | Recruiting |
| Sint Franciscus Vlietland Groep Stichting | Rotterdam | Netherlands | Recruiting |
| Haga Hospital | 's-Gravenhage | Netherlands | Recruiting |
| Haaglanden Medisch Centrum Stichting | 'S-Gravenhage | Netherlands | Recruiting |
| Jeroen Bosch Ziekenhuis Stichting | 'S-Hertogenbosch | Netherlands | Recruiting |
| Ziekenhuis Rivierenland | Tiel | Netherlands | Recruiting |
| Stichting Elisabeth-TweeSteden Ziekenhuis | Tilburg | Netherlands | Recruiting |
| Bernhoven B.V. | Uden | Netherlands | Recruiting |
| Universitair Medisch Centrum Utrecht | Utrecht | Netherlands | Recruiting |
| Diakonessenhuis Stichting | Utrecht | Netherlands | Recruiting |
| Stichting Viecuri Medisch Centrum voor Noord-Limburg | Venlo | Netherlands | Recruiting |
| Isala Klinieken Stichting | Zwolle | Netherlands | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.