The rimegePant in RElation to obeSiTy in mIGrainE study

Prior treatment

• Current use of medication that might interfere with the measurements (such as raloxifene, tamoxifen, Mg2+ supplementation, or chronic use of analgesics)
• Current pregnancy or breastfeeding, a positive pregnancy test prior to dispensing the investigational study medication, at baseline, or planning to become pregnant before or during the study
• Current or former non-incidental smoking (all substances), (incidental smoking is defined as a maximum of 1 cigarette per month), and/or alcohol consumption of more than seven alcohol units per week, and/or current or prior substance dependence/addition (alcohol, illicit drugs, narcotics, tranquilizers, analgesics)

Other illness

• History of migraine or current migraine (including aura without headache), or cluster headache, as determined with the official International Classification of Headache Disorders (version 3)
• Medical history of self-reported symptoms of conditions related to cardiovascular disease, metabolic and hormonal disease, infectious disease, skin disorders, psychiatric disorders
• History of sensitivity to fruits of capsicum plants (e.g. chili peppers)

Other

• Females who are inconsistent in administering their daily oral contraception, defined as forgetting their contraception tablets more than once a week
• Insufficient mastery of Dutch or English

• Written informed consent must be obtained from the subjects in accordance with the requirements of the ethics committee, prior to the initiation of protocol procedures
• Body mass index: between 18.5 to 22 kg/m2 or ≥30 kg/m2
• Males and females aged between 18 and 30 years
• General good health, based on their self-reported medical history
• All females should have a regular menstrual cycle of 25-35 days or only use oral hormonal contraceptive regularly and consistently for at least one month