2024-513366-18-00Active, not recruitingPhase 2
Phase II, multicenter, open-label, randomized, controlled, open-label clinical trial to eliminate the latent reservoir of HIV-1 by administration of high doses of antiretroviral drugs.
Source: EU CTIS (euclinicaltrials.eu) · Last updated 10 Apr 2026
Brief summary (registry, in English)
To evaluate the variation in the size of the latent cellular reservoir of HIV-1 after reaching inhibitory tissue concentrations by administration of high doses of antiretroviral drugs.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- First submitted
- 4 Jun 2024
- Start date
- 7 Apr 2025
- Lead sponsor
- Fundacion Para La Investigacion Biomedica Del Hospital Universitario Ramon Y Cajal
- Diseases
- HIV
- EU CT number
- 2024-513366-18-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 24
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Lab values
- Chronic Hepatitis B (HBsAg +) - Untreated chronic hepatitis C - Viral tropism X4
- Impaired renal function (plasma creatinine >1.5 mg/dl, creatinine clearance <60 ml/min/1.73 m2).
- Concomitant treatment with cytochrome CYP3A inducing or inhibiting drugs
Who the study is looking for
- Undetectable plasma viral load (<50 copies of HIV RNA in blood plasma) for at least 12 months prior to inclusion. ● Antiretroviral treatment with a triple regimen containing an integrase inhibitor. ● R5 viral tropism, determined in proviral DNA.
Age in the registry: 18 years to 64 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ramón y Cajal University Hospital Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Universitario 12 de Octubre Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.