2024-513575-40-01Not yet recruitingPhase 3
GLUTAMICS III
Glutamate infusion for prevention of Acute Kidney Injury in surgery for ischemic heart disease: (GLUTAMICS III = GLUTAmate for Metabolic Intervention in Coronary Surgery III)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 4 Jun 2026
Brief summary (registry, in English)
To establish the efficacy of intravenous glutamate infusion to prevent acute kidney injury (AKI) after coronary artery bypass surgery (CABG) among high-risk patients without diabetes.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 380 (estimated)
- First submitted
- 17 Jun 2024
- Start date
- 1 Oct 2027
- Lead sponsor
- Region Oestergoetland
- Diseases
- Heart failure
- EU CT number
- 2024-513575-40-01
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 380
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Lab values
- Diabetes; ambiguous food allergy known to have elicited flushing, headache, rash or asthma; age > 85 years; previous cardiac surgery; informed consent not possible because of critical condition or other reason; preoperative use of inotropic support or mechanical circulatory assist; preoperative dialysis or calculated Creatinine clearance < 30 mL/min; surgery without heart-lung machine (off-pump); concomitant Maze-procedure; surgery of ascending aorta necessitating circulatory arrest; surgery of both aortic and mitral valve.
Who the study is looking for
- Adult patients without diabetes operated on heart-lung machine with CABG of at least two vessel disease or left main stenosis with or without a concomitant procedure and who either have EuroSCORE II ≥ 3.0 to which at least one cardiac or procedure related risk factor contribute or Left Ventricular Ejection Fraction ≤ 0.30 regardless of EuroSCORE II
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sahlgrenska University Hospital-Vaestra Goetalandsregionen Coordinator of this site? Confirm its status | Goteborg | Sweden | Not yet recruiting |
| Region Oestergoetland Coordinator of this site? Confirm its status | Linkoping | Sweden | Not yet recruiting |
| Region Skane Skanes Universitetssjukhus Coordinator of this site? Confirm its status | Lund | Sweden | Not yet recruiting |
| Region Oerebro Laen Coordinator of this site? Confirm its status | Orebro | Sweden | Not yet recruiting |
| Uppsala University Hospital Coordinator of this site? Confirm its status | Uppsala | Sweden | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.