2024-514647-29-01RecruitingPhase 2
Early intervention in plaque psoriasis: is bimekizumab able to delay chronic inflammation? Prospective multicenter interventional study
EARLYPSO Early intervention in plaque psoriasis: is bimekizumab able to delay chronic inflammation? Prospective multicenter interventional study
Source: EU CTIS (euclinicaltrials.eu) · Last updated 5 Aug 2026
Brief summary (registry, in English)
To compare efficacy of bimekizumab versus topical corticosteroids on psoriasis clinical disease activity, assessed by PGA, at week 16 and week 24.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 12 Sept 2024
- Start date
- 22 Jul 2025
- Lead sponsor
- Centre Hospitalier Universitaire De Nice
- Diseases
- Psoriasis
- EU CT number
- 2024-514647-29-01
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 40
- 8 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
AI-kivonat: who the study is looking for
Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with mild plaque psoriasis, without psoriatic arthritis, who have a lesion on the elbows, knees or lower back. It compares bimekizumab with topical corticosteroids.
- Age
- 18 years or older and under 45 years
- Sex
- Men and women
- Disease stage
- Mild plaque psoriasis with PASI above 2 and below 6, no psoriatic arthritis, at least one lesion on the elbows, knees or lower back. Disease must have lasted less than 6 months or more than 2 years.
Main reasons for not taking part
- Pregnant or breast-feeding women
- Women who could have children and do not use contraception or plan to become pregnant during the study
- Psoriasis that is not plaque psoriasis
- Any contraindication to bimekizumab or topical steroids, such as cancer in the last 5 years, active infection or latent tuberculosis
- Taking part in another drug trial that could interfere with this evaluation
Read by machine on 9 Nov 2026.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants in other clinical therapeutic studies involving a drug that could interfere with the present evaluation
Age
- Any contraindication to bimekizumab or topical steroids, including but not limited to history of cancer<5 years, active infection, latent tuberculosis.
Other
- Pregnant or breast-feeding women. Or women with potential childbearing and not taking contraceptives or who plan to get pregnant during the study duration.
- Non plaque psoriasis
- Vulnerable people: minors, adult under guardianship or deprived of freedom
Who the study is looking for
- Men and women
- Patient willing and able to attend all study visits
- ≥ 18 and <45 years
- Plaque psoriasis without psoriatic arthritis
- Patients with mild psoriasis PASI >2 and <6
- Patient with at least one lesion on the elbows, the knees, or the lower back (additional lesions in other areas on top are allowed)
- Disease duration less than 6 months (short duration psoriasis) or >2 years (long duration psoriasis)
- For women of child-bearing age, an effective contraception (estroprogestative pill, contraceptive implant, IUD, condoms or tubal ligation) should be used for more than one month before the inclusion in the study. A urine pregnancy test (βHCG in urines) will be performed.
- Affiliation to a social security system
- Signed informed consent
Age in the registry: 18 years to 64 years · Sex: All · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre Hospitalier Universitaire Grenoble Alpes | Grenoble Cedex 9 | France | Recruiting |
| Hospital Edouard Herriot | Lyon Cedex 03 | France | Recruiting |
| Hôpital Saint Joseph | Marseille | France | Recruiting |
| Du Docteur Ruer S.E.L.A.R.L. | Martigues | France | Recruiting |
| Centre Hospitalier Universitaire de Nice | Nice | France | Recruiting |
| Centre Hospitalier Universitaire De Saint Etienne | St Etienne Cedex 2 | France | Recruiting |
| Centre Hospitalier Intercommunal Toulon / La Seine-Sur-Mer | Toulon | France | Recruiting |
| Medipole Hopital Prive | Villeurbanne Cedex | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.