2024-516642-19-01CompletedPhase 4
HOPE study
A randomized trial on Hemodynamic Optimization of cerebral Perfusion after Endovascular therapy in patients with acute ischemic stroke (HOPE study)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 7 Jul 2025
Brief summary (registry, in English)
Compare the clinical benefit of standard blood pressure management after mechanical thrombectomy versus a specific protocol aimed at hemodynamic optimization, where blood pressure targets are applied based on the degree of recanalization achieved during the procedure. Compare the clinical benefit of standard blood pressure management after mechanical thrombectomy versus a specific protocol aimed at hemodynamic optimization, where blood pressure targets are applied based on the degree of recanalization achieved during the procedure.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 814 (actual)
- First submitted
- 5 Nov 2024
- Start date
- 16 Jun 2021
- Lead sponsor
- Fundacio Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau
- Diseases
- Stroke
- EU CT number
- 2024-516642-19-01
- EudraCT number
- 2021-000022-10
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 814
- 15 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of MAO inhibitors
Other illness
- History of intracerebral hemorrhage
- Patient with congestive heart failure or unstable or recent coronary artery disease (<3 months)
- Any visible hemorrhage on the initial CT scan
- History of ventricular arrhythmias
Other
- ASPECTS score < 6
- Inclusion in other clinical trials.
- Occlusion in the vertebral, basilar, A2, P2, and M3-4 arteries.
- Pregnant or lactating patient
- Dissection of the aorta, cervical, or cerebral arteries, or unruptured aortic/cerebral aneurysm or known arteriovenous malformation
Who the study is looking for
- Patients with acute ischemic stroke and large intracranial vessel occlusion within 24 hours of symptom onset who have undergone mechanical thrombectomy.
- Successful recanalization, defined as a TICI score of 2b, 2c, or 3.
- Prior score on the modified Rankin Scale (mRS) of 0, 1, or 2.
- The patient or their legal representative provides informed consent in writing or verbally.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (15)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital General Universitario Dr. Balmis | Alicante | Spain | Completed |
| Hospital Universitario de Cruces | Barakaldo | Spain | Completed |
| Hospital de la Santa Creu i Sant Pau | Barcelona | Spain | Completed |
| Hospital del Mar | Barcelona | Spain | Completed |
| Hospital Universitari de Girona Doctor Josep Trueta | Girona | Spain | Completed |
| University Clinical Hospital Virgen De La Arrixaca | Murcia | Spain | Completed |
| Hospital Universitario Central De Asturias | Oviedo | Spain | Completed |
| Hospital Universitario De Salamanca | Salamanca | Spain | Completed |
| Complexo Hospitalario Universitario De Santiago | Santiago de Compostela | Spain | Completed |
| University Hospital Virgen Del Rocio S.L. | Sevilla | Spain | Completed |
| Hospital Universitari Joan XXIII de Tarragona | Tarragona | Spain | Completed |
| Hospital Universitario Y Politecnico La Fe | Valencia | Spain | Completed |
| Hospital Clinico Universitario de Valencia | Valencia | Spain | Completed |
| Hospital Universitario Miguel Servet | Zaragoza | Spain | Completed |
| Complexo Hospitalario Universitario A Coruña (La Coruña, Spain) | - | Spain | Completed |
This page is information, not medical advice. Discuss any trial with your doctor.