2024-516954-24-00RecruitingPhase 2
MRI of Neurometabolic Impairment in ALS and TIA Using Hyperpolarized Pyruvate
Source: EU CTIS (euclinicaltrials.eu) · Last updated 29 Jul 2026
Brief summary (registry, in English)
This project seeks to detect and characterize metabolic impairment in patients with Amyotrophic Lateral Sclerosis and patients with Transient Ischemic attack with a new MRI technique termed Hyperpolarized Pyruvate MRI
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 46 (estimated)
- First submitted
- 15 Aug 2024
- Start date
- 1 May 2020
- Lead sponsor
- Aarhus Universitet
- Diseases
- ALS (motor neurone disease)
- EU CT number
- 2024-516954-24-00
- EudraCT number
- 2020-000352-36
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 46
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindications for MRI with contrast: Chronic kidney disease,- Significant cardiac disease such as severe left ventricular outflow obstruction, -Significant obstructive lung disease or severe asthma,- Pacemaker, neurostimulator or cholera implant,- Metal foreign bodies such as fragments and irremovable piercings,- Unsafe medical implants (safety of heart valves, hips and the like must be confirmed),- Intracranial clips or coils,- Claustrophobia,- Largest circumference including arms > 160 cm. Competing neurological, psychiatric, liver or systemic disease including diabetes (except prior TIA, unspecific brain MRI findings, hypertension, atherosclerosis and hyperlipidemia/cholesterolemia which are allowed). Allergy to pyruvate.
Who the study is looking for
- All participants: 1) Age 18-85 years. 2) Pre-menopausal women must be confirmed non-pregnant by an onsite test. ALS group: 1) Fulfilling the 2021 Gold Coast criteria. 2) Upper motor neuron symptoms. TIA-group: 1) TIA within the last 10 days. 2) Symptoms must include unilateral weakness of limb or face. 3) Duration af symptoms minimum 10 minutes
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aarhus Universitet | Aarhus N | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.