Filgotinib bridging in newly diagnosed rheumatoid arthritis patients (FAST RA trial); A pragmatic randomized controlled non-inferiority low intervention clinical trial

Brief summary (registry, in English)

To investigate non-inferiority and potential superiority in achieving disease activity remission at 3 months of bridging with a JAK inhibitor (Filgotinib 200 mg once daily for 3 months) versus bridging with corticosteroids (triamcinolone 120 mg single dose im) when starting with methotrexate and hydroxychloroquine therapy in rheumatoid arthritis patients.

What you commit to

• Study type: Interventional · Phase 4
• Planned participants: 168
• 1 site in 1 country
• Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.

AI-kivonat: who the study is looking for

Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with newly diagnosed rheumatoid arthritis who have never taken disease-modifying drugs (DMARDs). It compares two short-term treatments given at the start of methotrexate and hydroxychloroquine therapy.

Age

18 to 64 years

Sex

All sexes can join.

Disease stage

Newly diagnosed rheumatoid arthritis, diagnosed by a rheumatologist, with a DAS28-CRP score above 2.6 at the start.

Earlier treatment

Must never have taken DMARDs. No corticosteroids in the last three months.

Main reasons for not taking part

• Current or earlier treatment with DMARDs
• Risk of cardiovascular disease
• Risk of cancer, including current or long-term smoking
• Pregnancy, planned pregnancy or planning to father a child
• Corticosteroid use in the last three months

Read by machine on 9 Nov 2026.

Who cannot take part

Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.

Who the study is looking for

Age in the registry: 18 years to 64 years · Sex: All · Does not accept healthy volunteers

Full criteria on EU CTIS (euclinicaltrials.eu)

Sites (1)

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