2024-517931-29-00RecruitingPhase 4
[68Ga]FAPI PET/CT to detect fibroblast activity in pulmonary COVID patients with and without long-term health problems.
LIBERATE; From Inflammation Biomarkers to Remodelling (FAPI PET/CT) towards personalized diagnosis in post-acute sequelae of COVID-19
Source: EU CTIS (euclinicaltrials.eu) · Last updated 22 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
To assess if pulmonary fibroblast activity, measured by [68Ga]FAPI-PET/CT, is higher in patients with current long COVID dyspnea and fatigue compared to patients with resolved complaints.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 24 Sept 2024
- Start date
- 1 Jul 2025
- Lead sponsor
- Universitair Medisch Centrum Groningen
- Diseases
- Long COVID and ME/CFS
- EU CT number
- 2024-517931-29-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 60
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
AI-kivonat: who the study is looking for
Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who had COVID-19 and still have breathlessness or fatigue, and adults whose complaints went away. A special scan is used.
- Age
- Adults older than 20 years (the registry also lists a minimum age of 18 years).
- Sex
- All sexes can join.
- Disease stage
- Breathlessness or fatigue for more than 3 months after a confirmed SARS-CoV-2 infection. Group 1: Fatigue Severity Scale 4 or higher. Group 2: Fatigue Severity Scale below 4, after a previous score of 4 or higher.
- Biomarker or test result
- SARS-CoV-2 infection confirmed by PCR, a serology test, or a CO-RADS score of 4/5.
Main reasons for not taking part
- Cannot or will not give informed consent
- History of claustrophobia
- Cannot tolerate lying on the back for the PET/CT scans
Read by machine on 9 Nov 2026.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of claustrophobia or feeling of inability to tolerate supine position for the PET/CT scans.
Other
- Inability or unwilling to give informed consent.
Who the study is looking for
- Adult patients > 20 years
- Self-reported complaints of dyspnea or fatigue > 3 months after SARS-CoV-2 infection confirmed with PCR, serology test or COVID-19 Reporting and Data System (CO-RADS) score 4/5.
- Group 1: Fatigue Severity Scale ≥ 4 at time of [68Ga]FAPI PET/CT
- Group 2: Fatigue Severity Scale < 4 at time of [68Ga]FAPI PET/CT after having previously recorded score of ≥ 4 or equivalent.
- In addition, when insufficient when insufficient subjects can be included in group 2 ‘Healthy’ controls will be included from the Lifelines or PARASOL cohort with the following criteria: Patients without self-reported complaints and past SARS-CoV-2 infection (which would have resulted in a Fatigue Severity Scale < 4) or without experienced confirmed SARS-CoV-2 infection.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Medical Center Groningen | Groningen | Netherlands | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.