2024-519407-99-00Not yet recruitingPhase 4
A randomized controlled trial of the effect of anesthetic dose during electroconvulsive therapy for major depression
Thiopental Induction Dose during Electroconvulsive therapy for depression (TIDE) - a randomized controlled trial of the effect of anesthetic dose during electroconvulsive therapy for major depression
Source: EU CTIS (euclinicaltrials.eu) · Last updated 15 Jul 2026
Brief summary (registry, in English)
The main objective of this trial is to to test if the reduction of depressive symptoms after six electroconvulsive therapy (ECT) sessions is larger in patients anesthetized with a low thiopental dose compared to patients anesthetized with a high thiopental dose during ECT.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 210 (estimated)
- First submitted
- 18 Dec 2024
- Start date
- 13 Jan 2025
- Lead sponsor
- Karolinska Institutet
- Diseases
- Depression
- EU CT number
- 2024-519407-99-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 210
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- postpartum depression • schizophrenia • psychotic syndrome • bipolar disorder • patients for whom the anesthesiologist deems that a high anesthetic dose is inappropriate due to a somatic condition. • patients under compulsory psychiatric care according to the Swedish Act on Compulsory Psychiatric Care (Lagen om psykiatrisk tvångsvård) • patients who do not speak or understand Swedish or English sufficiently to provide informed consent or complete study assessments
Who the study is looking for
- age 18 years and above • hospitalized patients with an ongoing major depressive episode within MDD
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sahlgrenska University Hospital-Vaestra Goetalandsregionen | Goteborg | Sweden | Not yet recruiting |
| Region Oerebro Laen | Orebro | Sweden | Not yet recruiting |
| Region Stockholm – SLSO | Stockholm | Sweden | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.