2025-520792-67-00Not yet recruitingPhase 3
A phase III trial of a De-escalated Immune-strategy During first-line treAtment in patients with metastatic non-small Cell lung cancer (NSCLC): DIDaC
Source: EU CTIS (euclinicaltrials.eu) · Last updated 12 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
To evaluate the efficacy of shorter duration of standard of care treatment ([chemo]immunotherapy) for patients with metastatic NSCLC
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 500 (estimated)
- First submitted
- 9 Jun 2025
- Start date
- 1 Aug 2025
- Lead sponsor
- Leids Universitair Medisch Centrum (LUMC)
- Diseases
- Lung cancer
- EU CT number
- 2025-520792-67-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 500
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any contra-indication (as per label) for treatment with immune checkpoint inhibitors
Other illness
- Other systemic anti-cancer treatment for the disease under study other than the first line (chemo-)immunotherapy
Who the study is looking for
- Advanced, metastatic non-small cell lung cancer UICC stage IV
- Having received first line immunotherapy or first line (chemo)immunotherapy for 6 months ±2 weeks
- Response or stable disease according to RECIST 1.1 as determined by imaging no older than 3 weeks at moment of randomization
- Signed and dated informed consent.
- ECOG PS 0-2 and fit and willing to continue treatment with first line (chemo-)immunotherapy as deemed by the treating physician
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting | Amsterdam | Netherlands | Not yet recruiting |
| Gelre Hospitals | Apeldoorn | Netherlands | Not yet recruiting |
| Het Van Weel-Bethesda Ziekenhuis | Dirksland | Netherlands | Not yet recruiting |
| Albert Schweitzer Ziekenhuis | Dordrecht | Netherlands | Not yet recruiting |
| Leids Universitair Medisch Centrum (LUMC) | Leiden | Netherlands | Not yet recruiting |
| Haga Hospital | 's-Gravenhage | Netherlands | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.