2025-521564-35-00RecruitingPhase 2
Cangrelor in endovascular stroke treatment with emergent carotid artery stenting (CANCAS)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 22 Jul 2026
Brief summary (registry, in English)
To assess the safety and efficacy of IV Cangrelor in patients with acute ischaemic stroke and large vessel occlusion of the intracranial carotid artery or first two segments of the middle cerebral artery (carotid artery territory) and concomitant symptomatic atherosclerotic extracranial carotid artery stenosis (≥50%) requiring mechanical thrombectomy and emergent extracranial carotid artery stenting.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 18 Jul 2025
- Start date
- 6 Nov 2025
- Lead sponsor
- Medical University Of Graz
- Diseases
- Stroke
- EU CT number
- 2025-521564-35-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 50
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Active pre-treatment with a P2Y12 inhibitor (e.g. Clopidogrel, Ticagrelor, Prasugrel
- Pre-treatment with oral anticoagulants in a therapeutic dosage
- Prohibited concomitant therapies
Other illness
- High intra- or extracranial bleeding risk according to the judgement of the treating stroke physicians (history of severe bleeding disorders, known haemophilia, severe liver disease, thrombocytopenia <100,000/µL, coagulation factor abnormalities, recent major surgery, recent major trauma, large brain infarct size
- Uncontrolled hypertension
- The patient’s medical history reveals a known allergy to any of the medications being used or their constituents, or to medications with a similar chemical structure
Other
- Non-atherosclerotic carotid artery stenosis (e.g. dissection)
- Known pregnancy (for women with childbearing potential a negative pregnancy test is required)
- Simultaneous participation in another interventional clinical trial
Who the study is looking for
- Adult patients (≥18 years of age)
- Large vessel occlusion stroke of the anterior cerebral circulation (carotid artery territory)
- Concomitant ipsilateral atherosclerotic carotid artery stenosis ≥50% requiring mechanical thrombectomy and emergent carotid artery stenting
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of Graz | Graz | Austria | Recruiting |
| Medizinische Universitaet Innsbruck | Innsbruck | Austria | Recruiting |
| Gemeinnuetzige Salzburger Landeskliniken Betriebsgesellschaft mbH | Salzburg | Austria | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.