2025-521681-10-00Active, not recruitingPhase 2
Study of zoldonrasib in Previously Treated Patients with RAS G12D-Mutant Non-Small Cell Lung Cancer (NSCLC)
A Phase 2, Open-Label, Multicenter Study of Zoldonrasib(RMC-9805) in Previously Treated Patients with RAS G12DMutant Non-Small Cell Lung Cancer (NSCLC) – Subprotocol D
Source: EU CTIS (euclinicaltrials.eu) · Last updated 26 Aug 2026
Brief summary (registry, in English)
To evaluate the ORR as assessed by RECIST v1.1 criteria of zoldonrasib monotherapy in patients with RAS G12D-mutant NSCLC who have been previously treated with systemic therapy
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 91 (estimated)
- First submitted
- 28 May 2025
- Start date
- 2 Oct 2025
- Lead sponsor
- Revolution Medicines Inc.
- Diseases
- Lung cancer
- EU CT number
- 2025-521681-10-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 91
- 42 sites in 9 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients that have gastrointestinal problems that may affect absorption of the study drug medicine
- Patients thathad any major surgery in the last 4 weeks.
- Patients that have previously taken targeted therapy for KRAS mutation.
Other illness
- Patients that have any other medical condition that may interfere with the study medicine.
- Patient that have a history of severe allergic reactions to the study medicine.
Other
- Patients that have primary brain and spinal cord tumor.
Who the study is looking for
- Patients that are at least 18 years of age
- Patients that have NSCLC with RAS-G12D mutation
- Patients that have had cancer treatment before or are not able to tolerate regular treatments.
- Patients that have at least 1 measurable tumor (lesion).
- Patients that have adequate organ function (bone marrow, liver, kidney) and blood clotting.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (42)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Noe LGA Gesundheit Region Mitte GmbH | St. Poelten | Austria | Completed |
| Stadt Wien Wiener Gesundheitsverbund | Vienna | Austria | Completed |
| Nemocnice AGEL Nový Jičín a.s. | Nový Jičín | Czechia | Completed |
| Charite Universitaetsmedizin Berlin KöR | Berlin | Germany | Completed |
| University Hospital Cologne AöR | Cologne | Germany | Completed |
| Technische Universitaet Dresden | Dresden | Germany | Completed |
| Goethe University Frankfurt | Frankfurt Am Main | Germany | Completed |
| Rigshospitalet | Copenhagen Oe | Denmark | Completed |
| Odense University Hospital | Odense C | Denmark | Completed |
| Complexo Hospitalario Universitario A Coruña | A Coruña | Spain | Active, not recruiting |
| Hospital Universitari Vall d'Hebron | Barcelona | Spain | Active, not recruiting |
| Hospital Universitario Fundación Jiménez Díaz | Madrid | Spain | Active, not recruiting |
| Clinica Universidad de Navarra | Madrid | Spain | Active, not recruiting |
| Hospital Clínico San Carlos | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Ramón y Cajal | Madrid | Spain | Active, not recruiting |
| Hospital Universitario 12 de Octubre | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Regional de Málaga | Málaga | Spain | Active, not recruiting |
| Clínica Universidad de navarra | Pamplona | Spain | Active, not recruiting |
| University Hospital Virgen Del Rocio S.L. | Sevilla | Spain | Active, not recruiting |
| Hospital Universitario Y Politecnico La Fe | Valencia | Spain | Active, not recruiting |
| Fundación Instituto Valenciano de Oncología | Valencia | Spain | Active, not recruiting |
| Institut Bergonie | Bordeaux | France | Active, not recruiting |
| Hôpital Ambroise-Paré | Boulogne-Billancourt | France | Active, not recruiting |
| Hospices Civils de Lyon | Bron | France | Active, not recruiting |
| Centre Francois Baclesse | Caen Cedex 5 | France | Active, not recruiting |
| Centr Georges Francois Leclerc | Dijon | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Lille | Lille | France | Active, not recruiting |
| Assistance Publique Hopitaux de Paris | Paris | France | Active, not recruiting |
| Institut Curie | Paris | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Nantes | Saint-Herblain | France | Active, not recruiting |
| Hospital Foch | Suresnes | France | Active, not recruiting |
| Oncopole Claudius Regaud | Toulouse Cedex 9 | France | Active, not recruiting |
| Institut Gustave Roussy | Villejuif | France | Active, not recruiting |
| Thoracic General Hospital of Athens "I Sotiria" | Athens | Greece | Completed |
| Henry Dunant Hospital Center | Athens | Greece | Completed |
| ASST Grande Ospedale Metropolitano Niguarda | Milan | Italy | Active, not recruiting |
| Azienda Ospedaliero-Universitaria San Luigi Gonzaga | Orbassano | Italy | Active, not recruiting |
| Azienda Unità Sanitaria Locale della Romagna | Ravenna | Italy | Active, not recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Rome | Italy | Active, not recruiting |
| Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting | Amsterdam | Netherlands | Active, not recruiting |
| Leids Universitair Medisch Centrum (LUMC) | Leiden | Netherlands | Active, not recruiting |
| Universitair Medisch Centrum Utrecht | Utrecht | Netherlands | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.