2025-522640-41-00RecruitingPhase 2
A Study to Evaluate Brenipatide Compared with Placebo in Adult Participants with Uncontrolled Moderate to Severe Asthma
J2S-MC-GZMR: A Phase 2, Multicenter, Randomized, Double-blind, 52-week Study, to Investigate the Efficacy and Safety of Brenipatide Compared with Placebo for the Treatment of Adult Participants with Uncontrolled Moderate to Severe Asthma
Source: EU CTIS (euclinicaltrials.eu) · Last updated 26 Aug 2026
Brief summary (registry, in English)
To evaluate the efficacy of brenipatide relative to placebo in reducing severe asthma exacerbations
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 137 (estimated)
- First submitted
- 26 Sept 2025
- Start date
- 13 Feb 2026
- Lead sponsor
- Eli Lilly & Co.
- Diseases
- Asthma
- EU CT number
- 2025-522640-41-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 137
- 29 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- Participants must not have a Lung condition other than asthma, such as smoker’s lung, infections that has been going on for a long time or didn’t go away completely
Other
- Participants must not have a Diagnosis of job-related asthma
Who the study is looking for
- Participants must have been diagnosed with asthma and have received an asthma controller medication prescribed by their doctor for at least 12 months prior to screening
- Participants must have a history of 1 severe asthma exacerbation that led to oral steroid treatment in the last 12 months prior to screening
Age in the registry: 18 years to 64 years · Sex: All · Does not accept healthy volunteers
Sites (29)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| KPPK GmbH | Bendorf | Germany | Recruiting |
| Studienpraxis Berlin-Brandenburg Cornelia Seelbinder Und Lennart Schaper GbR | Berlin | Germany | Recruiting |
| Ruhrlandklinik Westdeutsches Lungenzentrum Am Universitaetsklinikum Essen gGmbH | Essen | Germany | Recruiting |
| Universitaetsklinikum Essen (AoR) | Essen | Germany | Recruiting |
| IKF Pneumologie GmbH & Co. KG | Frankfurt am Main | Germany | Recruiting |
| ME Clinical Respiratory Research Hamburg GmbH | Hamburg | Germany | Recruiting |
| POIS Sachsen GmbH | Leipzig | Germany | Recruiting |
| IKF Pneumologie GmbH & Co. KG | Mainz | Germany | Recruiting |
| Dedicated Research Site FutureMeds | Offenbach | Germany | Recruiting |
| Centre Hospitalier Du Pays D Aix Centre Hospitalier Intercommunal Aix-Pertuis | Aix En Provence | France | Recruiting |
| Centre Hospitalier Régional et Universitaire de Brest | Brest | France | Recruiting |
| Centre Hospitalier de Cholet | Cholet | France | Recruiting |
| Centre Hospitalier De Versailles | Le Chesnay Cedex | France | Recruiting |
| Assistance Publique Hopitaux De Paris | Le Kremlin-Bicetre | France | Recruiting |
| Groupe Hospitalier Intercommunal Le Raincy Montfermeil | Montfermeil | France | Recruiting |
| Assistance Publique Hopitaux De Paris | Paris Cedex 18 | France | Recruiting |
| Centre Hospitalier Universitaire de Bordeaux | Pessac | France | Recruiting |
| Centre Hospitalier Universitaire de Rennes | Rennes | France | Recruiting |
| Hospital Foch | Suresnes | France | Recruiting |
| EB FlevoResearch B.V. | Almere | Netherlands | Recruiting |
| Amphia Hospital | Breda | Netherlands | Recruiting |
| Canisius Wilhelmina Ziekenhuis | Nijmegen | Netherlands | Recruiting |
| Sint Franciscus Vlietland Groep Stichting | Rotterdam | Netherlands | Recruiting |
| Gelre Hospitals | Zutphen | Netherlands | Recruiting |
| Isala Klinieken Stichting | Zwolle | Netherlands | Recruiting |
| Centrum Medyczne All-Med Badania Kliniczne | Cracow | Poland | Recruiting |
| Diamond Clinic Sp. z o.o. | Cracow | Poland | Recruiting |
| Alergologia Plus sp. z o.o. | Poznan | Poland | Recruiting |
| Specjalistyczna Przychodnia Lekarska Alergo-Med Sp. z o.o | Poznan | Poland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.