2025-522970-35-00RecruitingPhase 4
The REVERT-PREDIABETES trial
REVERsal to normoglycemia by Treating PREDIABETES: the REVERT-PREDIABETES trial
Source: EU CTIS (euclinicaltrials.eu) · Last updated 23 Nov 2025
Brief summary (registry, in English)
To examine the proportion of patients with angiographically documented coronary artery disease that can be reverted from prediabetes to normoglycemia by using cardioprotective glucose-lowering drugs.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 158 (estimated)
- First submitted
- 11 Aug 2025
- Start date
- 3 Mar 2026
- Lead sponsor
- Region Midtjylland
- Diseases
- Coronary artery disease
- EU CT number
- 2025-522970-35-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 158
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous pancreatitis
Other illness
- Heart failure with NYHA class III or IV
- Anemia, recent bleeding or blood transfusion (<3 months)
- Known hemoglobinopathy and other conditions with effect on erythrocyte lifespan
Lab values
- eGFR <30 mL/min/1.73 m2
- Previous diabetes diagnosis, previous HbA1c >47 mmol/mol, or current/previous usage of diabetes medication
- Intake of medications with known effect on HbA1c validity
Other
- Pregnancy, breastfeeding, or fertile women who do not use highly effective birth control
- Strongly reduced liver function
- Chronic alcohol abuse
Who the study is looking for
- Chronic coronary syndrome with documented coronary artery disease. In the case of previous myocardial infarction, at least 30 days between the event and randomization is required.
- Prediabetes defined as HbA1c 42-47 mmol/mol OR normoglycemia defined as HbA1c <39 mmol/mol
- Age 18 to 80 years
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Region Midtjylland | Aarhus N | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.