2025-523709-13-00Not yet recruitingPhase 3
SAVE trial
Sevoflurane vs. propofol for general Anesthesia in patients with acute ischemic stroke treated with endoVascular treatmEnt (SAVE trial)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 7 Apr 2026
Brief summary (registry, in English)
Compare the final volume of cerebral infarction by magnetic resonance imaging at 72 hours in patients with acute ischemic stroke undergoing mechanical thrombectomy under general anesthesia, who are randomly assigned to receive anesthetic maintenance with sevoflurane or propofol.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 330 (estimated)
- First submitted
- 14 Jan 2026
- Start date
- 1 Mar 2026
- Lead sponsor
- Fundacio Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau
- Diseases
- Stroke
- EU CT number
- 2025-523709-13-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 330
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
AI-kivonat: who the study is looking for
Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with an acute stroke caused by a blocked brain artery, who are having an emergency procedure to remove the clot and need general anesthesia.
- Age
- Older than 18 years.
- Sex
- All sexes can join.
- Disease stage
- Acute ischemic stroke within 24 hours from the last time the person was seen well. Blockage in the front part of the brain circulation (M1 or M2 of the middle cerebral artery, or the end of the internal carotid artery). ASPECTS score of 6 or more on the first CT scan. Before the stroke, mRS score of 0 to 3.
- Earlier treatment
- Emergency endovascular treatment (clot removal through the artery), with or without earlier clot-dissolving medicine. General anesthesia is needed at the start of the procedure.
Main reasons for not taking part
- Bleeding in the brain on the first CT scan
- Blockage in the anterior cerebral artery or in the back part of the brain circulation
- Unstable blood pressure or circulation
- Breathing failure needing a breathing tube
- Allergy to propofol or sevoflurane, or history of malignant hyperthermia
Read by machine on 9 Nov 2026.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of a previous severe adverse reaction to halogenated anesthetics, including hepatotoxicity associated with their use.
Other illness
- Acute respiratory failure requiring orotracheal intubation
- Known hypersensitivity to propofol, sevoflurane, or any of their excipients.
- Personal or family history of malignant hyperthermia, or suspected susceptibility to malignant hyperthermia (contraindication to halogenated anesthetics such as sevoflurane).
Other
- Presence of hemorrhagic lesions on baseline CT.
- Occlusions in the anterior cerebral artery (ACA).
- Occlusions in the posterior circulation, including vertebral, basilar, or posterior cerebral arteries (PCA).
- Hemodynamic instability.
- Decision to perform general anesthesia due to complications during the endovascular treatment.
Who the study is looking for
- Age >18 years
- Acute ischemic stroke within 24 hours from the last time seen well (LTSW), undergoing emergency endovascular treatment (EVT), with or without prior thrombolysis.
- Intracranial occlusion in the anterior circulation, including occlusions in segments M1 and M2 of the middle cerebral artery and/or the terminal portion of the internal carotid artery (TICA). Tandem lesions affecting extracranial segments of the internal carotid artery will also be included.
- Alberta Stroke Program Early CT Score (ASPECTS) ≥6 on baseline computed tomography (CT).
- Pre-stroke modified Rankin Scale (mRS) score of 0–3.
- Indication for general anesthesia at the start of the procedure (<30 minutes from femoral puncture) due to one of the following reasons: • Confusion or lack of patient cooperation. • Technical difficulties, such as complex arterial access, vascular tortuosity, need for extra- or intracranial stent placement, distal/medium vessel occlusions, among others. • Treating team's preference.
- Ability of the patient or the family member/legal representative to provide informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital de la Santa Creu i Sant Pau | Barcelona | Spain | Not yet recruiting |
| Hospital del Mar | Barcelona | Spain | Not yet recruiting |
| Hospital Universitario Donostia | Donostia | Spain | Not yet recruiting |
| Hospital Universitari de Girona Doctor Josep Trueta | Girona | Spain | Not yet recruiting |
| University Hospital Son Espases | Palma | Spain | Not yet recruiting |
| Hospital Universitario Marqués de Valdecilla | Santander | Spain | Not yet recruiting |
| Hospital Universitario Miguel Servet | Zaragoza | Spain | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.