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2025-524486-25-00Not yet recruitingPhase 1

A Multicentre, open label, Phase I-Ib Clinical Trial Combining Melanoma-Specific Peptide Vaccination (UniCanVax) and Anti PD-1 Inhibitor (Nivolumab) in Immune Checkpoint Blockade Refractory Metastatic or Unresectable Stage III/IV Melanoma Patients

Source: EU CTIS (euclinicaltrials.eu) · Last updated 3 Nov 2026

Next steps

Status (registry)
Not yet recruiting
Phase (registry)
Phase 1
Study type
Interventional
Enrollment
25 (estimated)
First submitted
13 Jul 2026
Start date
31 Oct 2026
Lead sponsor
Humanitas Mirasole S.p.A.
Diseases
Melanoma
EU CT number
2025-524486-25-00

What you commit to

  • Study type: Interventional · Phase 1
  • Planned participants: 25
  • 5 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.

AI-kivonat: who the study is looking for

Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with melanoma that has spread or cannot be removed by surgery, and that no longer responds to immune checkpoint blocker treatment. It tests a melanoma peptide vaccine (UniCanVax) together with nivolumab.

Age
18 years or older
Sex
All sexes can join
Disease stage
Metastatic or unresectable stage III/IV melanoma that is refractory to immune checkpoint blockade
Earlier treatment
Previous immune checkpoint blocker treatment that no longer works (refractory)

Read by machine on 9 Nov 2026.

Sites (5)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Fondazione IRCCS - Istituto Nazionale dei TumoriMilanItalyNot yet recruiting
IRCCS Istituto Nazionale Tumori Fondazione PascaleNaplesItalyNot yet recruiting
Istituto Oncologico VenetoPadovaItalyNot yet recruiting
Azienda Ospedaliera di PerugiaPerugiaItalyNot yet recruiting
Humanitas Mirasole S.p.A.RozzanoItalyNot yet recruiting

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This page is information, not medical advice. Discuss any trial with your doctor.