2025-524486-25-00Not yet recruitingPhase 1
A Multicentre, open label, Phase I-Ib Clinical Trial Combining Melanoma-Specific Peptide Vaccination (UniCanVax) and Anti PD-1 Inhibitor (Nivolumab) in Immune Checkpoint Blockade Refractory Metastatic or Unresectable Stage III/IV Melanoma Patients
Source: EU CTIS (euclinicaltrials.eu) · Last updated 3 Nov 2026
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 25 (estimated)
- First submitted
- 13 Jul 2026
- Start date
- 31 Oct 2026
- Lead sponsor
- Humanitas Mirasole S.p.A.
- Diseases
- Melanoma
- EU CT number
- 2025-524486-25-00
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 25
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
AI-kivonat: who the study is looking for
Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with melanoma that has spread or cannot be removed by surgery, and that no longer responds to immune checkpoint blocker treatment. It tests a melanoma peptide vaccine (UniCanVax) together with nivolumab.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Metastatic or unresectable stage III/IV melanoma that is refractory to immune checkpoint blockade
- Earlier treatment
- Previous immune checkpoint blocker treatment that no longer works (refractory)
Read by machine on 9 Nov 2026.
Sites (5)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fondazione IRCCS - Istituto Nazionale dei Tumori | Milan | Italy | Not yet recruiting |
| IRCCS Istituto Nazionale Tumori Fondazione Pascale | Naples | Italy | Not yet recruiting |
| Istituto Oncologico Veneto | Padova | Italy | Not yet recruiting |
| Azienda Ospedaliera di Perugia | Perugia | Italy | Not yet recruiting |
| Humanitas Mirasole S.p.A. | Rozzano | Italy | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.