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2025-524616-11-00RecruitingPhase 3

A Study to evaluate effect of AZD6234 in adult participants with Type 2 Diabetes Mellitus and obesity or overweight

A Phase III Randomized, Double-Blind, Placebo-Controlled Multicentre Trial to Evaluate the Efficacy and Safety of AZD6234 in Participants with Type 2 Diabetes Mellitus and Obesity or Overweight

Source: EU CTIS (euclinicaltrials.eu) · Last updated 9 Oct 2026

Next steps

Brief summary (registry, in English)

To evaluate the effect of AZD6234 as compared to placebo in percent body weight change from baseline at 68 weeks of treatment

Status (registry)
Recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
420 (estimated)
First submitted
25 Jun 2026
Start date
26 Oct 2026
Lead sponsor
AstraZeneca AB
EU CT number
2025-524616-11-00

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 420
  • 57 sites in 4 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.

AI-kivonat: who the study is looking for

Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with type 2 diabetes who are also overweight or have obesity. It compares AZD6234 with a placebo.

Age
18 years or older
Sex
Men and women
Disease stage
Type 2 diabetes diagnosed at least 90 days before screening, with BMI of 27 kg/m2 or more. HbA1c at screening of 6.0% to 10%, managed with diet and exercise alone or with a stable dose of an oral glucose-lowering medicine.
Earlier treatment
Must not have used a GLP-1 receptor agonist or GLP-1 medicine in the 3 months before randomisation. Must not have used insulin for type 2 diabetes in the 3 months before screening. Must have tried at least once, without success, to lose weight.
Biomarker or test result
HbA1c of 6.0% (42 mmol/mol) to 10% (86 mmol/mol) at screening.

Main reasons for not taking part

  • Obesity mainly caused by other hormone disorders
  • Type 1 diabetes or diabetes that is not clearly type 2
  • Ketoacidosis or hyperosmolar coma in the 3 months before screening
  • Significant liver or bile duct disease, or high liver test results at screening
  • Weight change of more than 5% in the 3 months before randomisation

Read by machine on 9 Nov 2026.

Who cannot take part

Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Type 1 diabetes mellitus (or any other diabetes mellitus that is not clearly Type 2 diabetes), OR have history of ketoacidosis or hyperosmolar coma/state within 3 months prior to Screening.
  • Has received treatment with a GLP-1 receptor agonist or GLP-1 containing medication for any indication within 3 months before Randomisation
  • Use of insulin therapy for T2DM within 3 months prior to screening

Other illness

  • Obesity primarily caused by other endocrine disorders

Lab values

  • Significant hepatobiliary disease and/or any of the following results at Screening: - ALT ≥ 3.0 X ULN - AST ≥ 3.0 X ULN - TBL > 1.5 X ULN (except for cases of known Gilbert’s Syndrome)

Who the study is looking for

  • Males & females ≥ 18 years of age
  • BMI ≥ 27 kg/m2
  • Diagnosed with T2DM ≥ 90 days prior to Screening.
  • HbA1c value at Screening of ≥ 6.0% (42 mmol/mol) and ≤ 10% (86 mmol/mol) managed with diet and exercise alone or with a stable dose of any oral glycaemic-lowering agent (as per local labelling).
  • Stable body weight (≤ 5% body weight change) for at least 3 months prior to Randomisation.
  • History of at least one self-reported unsuccessful attempt to lose body weight in lifetime.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on EU CTIS (euclinicaltrials.eu)

Sites (57)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Klinische Forschung Berlin-Mitte GmbHBerlinGermanyRecruiting
FutureMeds GmbHBerlinGermanyRecruiting
Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil gGmbHBochumGermanyRecruiting
Internistische GemeinschaftspraxisBündeGermanyRecruiting
Klinische Forschung Dresden GmbHDresdenGermanyRecruiting
IKF Pneumologie GmbH & Co. KGFrankfurt am MainGermanyRecruiting
ClinPhenomics CVC GmbHFrankfurt am MainGermanyRecruiting
Universitaetsklinikum Frankfurt AöRFrankfurt Am MainGermanyRecruiting
Medical Center- University of FreiburgFreiburg im BreisgauGermanyRecruiting
Universitaetsmedizin GoettingenGoettingenGermanyRecruiting
Velocity Clinical Research Germany GmbHHamburgGermanyRecruiting
Klinische Forschung Hamburg GmbHHamburgGermanyRecruiting
Klinische Forschung Hannover-Mitte GmbHHanoverGermanyRecruiting
Universitaetsklinikum des Saarlandes AöRHomburgGermanyRecruiting
Praxisgemeinschaft JerichowJerichowGermanyRecruiting
Klinische Forschung Karlsruhe GmbHKarlsruheGermanyRecruiting
Velocity Clinical Research Germany GmbHLeipzigGermanyRecruiting
Institut Fuer Praeventive Medizin & Klinische Forschung GbRMagdeburgGermanyRecruiting
IKF Pneumologie GmbH & Co. KGMainzGermanyRecruiting
Hausarztpraxis am HeimeranplatzMünchenGermanyRecruiting
FutureMeds GmbHOffenbach Am MainGermanyRecruiting
Klinische Forschung Schwerin GmbHSchwerinGermanyRecruiting
Complexo Hospitalario Universitario A CoruñaA CoruñaSpainRecruiting
Hospital Universitario de La RiberaAlziraSpainRecruiting
Hospital Universitari Vall d'HebronBarcelonaSpainRecruiting
Hospital Nisa Sevilla AljarafeCastilleja De La CuestaSpainRecruiting
Area Sanitaria De FerrolFerrolSpainRecruiting
Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De LleidaLleidaSpainRecruiting
Hospital Universitario Virgen de la VictoriaMálagaSpainRecruiting
Hospital Universitario Central De AsturiasOviedoSpainRecruiting
Hospital General de SegoviaSegoviaSpainRecruiting
Hospital Quironsalud Infanta LuisaSevillaSpainRecruiting
Kresmed Sp. z o. o.BialystokPolandRecruiting
Unicardia Specjalistyczne Centrum Leczenia Chorob Serca I Naczyn & Unimedica Specjalistyczne Centrum Medyczne & Uniestetica Centrum Chirurgii Plastycznej Rekonstrukcyjnej I Medycyny Estetycznej Malopolskie Kliniki Specjalistyczne Sp. z o.o.CracowPolandRecruiting
Linden Sp. z o.o. sp.k.CracowPolandRecruiting
Ambulatorium Sp. z o.o.ElblagPolandRecruiting
Pratia S.A.GdyniaPolandRecruiting
Salvia Lekston I Madej Sp. J.KatowicePolandRecruiting
Pratia S.A.KatowicePolandRecruiting
Beata Miklaszewicz & Dariusz Dabrowski Cardiamed Sp. j.LegnicaPolandRecruiting
Gabinet Lekarski Malgorzata Saryusz-WolskaLodzPolandRecruiting
Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.LodzPolandRecruiting
Uniwersyteckie Centrum Stomatologii i Medycyny Specjalistycznej Sp. z o.o.PoznanPolandRecruiting
Tevita Clinical Sp. z o.o.RadzionkowPolandRecruiting
Care Access Polska Sp. Z o.o.WarsawPolandRecruiting
Futuremeds Sp. z o.o.WarsawPolandRecruiting
Futuremeds Sp. z o.o.WroclawPolandRecruiting
DIABEDA s.r.o.BratislavaSlovakiaRecruiting
MediTask, s.r.oBratislavaSlovakiaRecruiting
PremedixBratislavaSlovakiaRecruiting
Medical Group Kosice s.r.oKošiceSlovakiaRecruiting
Cardio D&R s.r.o. KosiceKošiceSlovakiaRecruiting
IN-DIA s.r.o.LučenecSlovakiaRecruiting
MUDr. Kanderkova s.r.o.NamestovoSlovakiaRecruiting
MUDr. Jan Culak, s.r.o.PrievidzaSlovakiaRecruiting
Tatratrial s.r.o.RožňavaSlovakiaRecruiting
Areteus s.r.o.TrebišovSlovakiaRecruiting

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This page is information, not medical advice. Discuss any trial with your doctor.