2025-524679-22-00RecruitingPhase 2
Up-titration of sulfonylurea (SU) in individuals with HNF1A- and HNF4A-MODY – A Steno MODERN-MODY project (MM-SUUP)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 4 Mar 2026
Brief summary (registry, in English)
We aim to systematically assess the effects of up-titration of glimepiride on continuous glucose monitoring (CGM) metrics in individuals diagnosed with HNF1A- or HNF4A-MODY including those who have previously been treated as individuals with T1D or T2D.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 9 Dec 2025
- Start date
- 14 Apr 2026
- Lead sponsor
- Steno Diabetes Center Copenhagen
- Diseases
- Type 1 diabetes
- EU CT number
- 2025-524679-22-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 30
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with SU or glinides within the last 30 days
Other illness
- End-stage liver disease
- Known allergic reaction to study drug (glimepiride or other sulphonamides)
Lab values
- Nephropathy (eGFR <30 ml/min/1.73 m2 and/or persistent severely increased albuminuria (urine-albumin-creatinine ratio >300 mg/g))
Other
- Breastfeeding, pregnancy or inadequate contraceptive methods in women with childbearing potential
- Contraindications for use of specific CGM device (e.g. non-manageable skin reactions, use of substances interfering with measurements etc.)
Who the study is looking for
- HbA1c ≥48 mmol/mol and/or current insulin treatment
- Age ≥18 years
- Diabetes caused by a heterozygous mutation (pathogenic or likely pathogenic according to ACMG criteria) in the HNF1A-gene or HNF4A-gene
- Informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aarhus University Hospital | Aarhus N | Denmark | Recruiting |
| Steno Diabetes Center Copenhagen | Herlev | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.