Prevention of radiation-induced salivary gland damage by botulinum toxin application in patients with head and neck cancers

Brief summary (registry, in English)

To evaluate whether intraglandular application of botulinum toxin type A prior to radiotherapy preserves salivary gland function.

What you commit to

• Study type: Interventional · Phase 2
• Planned participants: 40
• 1 site in 1 country
• Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.

AI-kivonat: who the study is looking for

Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with head and neck squamous cell carcinoma who will have radiotherapy. It tests botulinum toxin type A injected into the salivary glands before radiotherapy to protect salivary gland function.

Age

18 years or older

Sex

All sexes can join.

Disease stage

Head and neck squamous cell carcinoma confirmed by tissue examination, with radiotherapy planned.

Earlier treatment

No earlier radiotherapy to the head and neck region.

Biomarker or test result

The submandibular salivary glands must work symmetrically on the Tc99m scintigraphy scan done before treatment.

Main reasons for not taking part

• Earlier radiotherapy to the head and neck region
• Known salivary gland disease, such as salivary stones or repeated gland inflammation
• Pregnancy or breastfeeding
• Known allergy to botulinum toxin or a nerve-muscle transmission disorder
• Earlier surgery affecting the major salivary glands (assessed case by case)

Read by machine on 9 Nov 2026.

Who cannot take part

Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.

Who the study is looking for

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on EU CTIS (euclinicaltrials.eu)

Sites (1)

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