2025-524829-40-00Not yet recruitingPhase 4
Effects of General Anaesthetic Agents on the Efficacy of Electroconvulsive Therapy and EEG Changes in Patients with Depression
Source: EU CTIS (euclinicaltrials.eu) · Last updated 7 Oct 2026
Brief summary (registry, in English)
The primary objective of the study is to determine whether the choice of anaesthetic agent (methohexital, propofol, or etomidate) influences the speed of clinical response to ECT during the treatment course measured by Montgomery-Åsberg depression scale (MARDS).
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 174 (estimated)
- First submitted
- 18 Jun 2026
- Start date
- 1 Sept 2026
- Lead sponsor
- Varsinais-Suomen hyvinvointialue
- Diseases
- Depression
- EU CT number
- 2025-524829-40-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 174
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Left-handedness 2. Personality disorder or active substance use disorder 3. Pregnancy or breastfeeding 4. Any degree of legal incapacity to provide legal consent 5. Patients receiving involuntary psychiatric treatment 6. Contraindications to study anaesthetic agents or neuromuscular blockers 7. Severe obesity (BMI > 45) 8. Epilepsy or use of antiepileptic medication for any reason (e.g., neuropathic pain) 9. Bipolar disorder (F31.x) 10. Non-affective psychotic disorders (F20–F29) 11. Clinically significant neurological disorders that are considered likely to interfere with EEG interpretation, seizure physiology, or the scientific validity of the study outcomes.
Who the study is looking for
- Written informed consent obtained prior to study procedures 2. Age 18–75 years 3. Diagnosis of severe unipolar depression requiring ECT (ICD-10: F32.1x, F32.2x, F32.3, F33.1x, F33.2x, F33.3) 4. Considered suitable for ECT by the treating psychiatrist 5. Patients undergoing their first acute course of ECT 6. Able to comply with study procedures and the scheduled ECT treatment series 7. ASA Physical status I-III
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Varsinais-Suomen hyvinvointialue | Turku | Finland | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.