2025-525016-41-00RecruitingPhase 2
A Phase IIb Study to Evaluate AZD8965 in Participants with Idiopathic Pulmonary Fibrosis (IPF)
A Phase IIb Study to Evaluate the Efficacy, Safety, and Tolerability of AZD8965 in Participants with Idiopathic Pulmonary Fibrosis (IPF)) (ARGiNAUT)
Source: EU CTIS (euclinicaltrials.eu) · Last updated 6 Oct 2026
Brief summary (registry, in English)
To evaluate the clinical efficacy of AZD8965 compared with placebo on the absolute change from baseline in FVC in mL at Week 24
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 139 (estimated)
- First submitted
- 20 Apr 2026
- Start date
- 4 Sept 2026
- Lead sponsor
- AstraZeneca AB
- Diseases
- Idiopathic pulmonary fibrosis
- EU CT number
- 2025-525016-41-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 139
- 68 sites in 10 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- Lower respiratory tract infection requiring treatment
- Acute coronary syndrome/acute myocardial infarction, unstable angina ± coronary intervention with Percutaneous Coronary Intervention, or Coronary Artery Bypass Grafting
- Heart failure
- History of organ transplantation or is likely to receive lung transplantation
Other
- ILD other than IPF
- The extent of emphysema is greater than the extent of fibrotic changes on chest HRCT scan
- Acute exacerbation of IPF
Who the study is looking for
- Age ≥ 40 years
- IPF diagnosis
- Participants with IPF receiving locally approved antifibrotic therapies at a stable dose, or participants with IPF not receiving local standard of care
- FVC ≥ 45% predicted of normal
- DLCO corrected for hemoglobin ≥ 25% predicted of normal
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (68)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical Center Pulmo - 2018 EOOD | Haskovo | Bulgaria | Not yet recruiting |
| University Multiprofile Hospital For Active Treatment Saint Georgi EAD | Plovdiv | Bulgaria | Not yet recruiting |
| Medical Center Hermes Ruse Ltd. | Ruse | Bulgaria | Not yet recruiting |
| Medical Center Pulmovision Ltd. | Sofia | Bulgaria | Not yet recruiting |
| Children's Health Medical Center EOOD | Sofia | Bulgaria | Not yet recruiting |
| Diagnostics And Consultation Center Convex Ltd. | Sofiya | Bulgaria | Not yet recruiting |
| Universitaetsklinikum Bonn AöR | Bonn | Germany | Recruiting |
| Ruhrlandklinik Westdeutsches Lungenzentrum Am Universitaetsklinikum Essen gGmbH | Essen | Germany | Recruiting |
| Medical Center- University of Freiburg | Freiburg im Breisgau | Germany | Recruiting |
| Philipps-Universitaet Marburg | Fulda | Germany | Recruiting |
| Justus-Liebig-Universitaet Giessen | Giessen | Germany | Recruiting |
| University Medical Center Hamburg-Eppendorf | Hamburg | Germany | Recruiting |
| Klinikum Region Hannover GmbH | Hanover | Germany | Recruiting |
| Thoraxklinik Heidelberg gGmbH | Heidelberg | Germany | Recruiting |
| Lungenklinik Hemer Deutscher Gemeinschafts-Diakonieverband GmbH | Hemer | Germany | Recruiting |
| Universitaet Leipzig | Leipzig | Germany | Recruiting |
| Universitaetsklinikum Schleswig-Holstein AöR | Luebeck | Germany | Recruiting |
| Zentrum fuer ambulante pneumologische Forschung Marburg GbR | Marburg | Germany | Recruiting |
| LMU Klinikum Muenchen AöR | Munich | Germany | Recruiting |
| Robert Bosch Krankenhaus GmbH | Stuttgart | Germany | Recruiting |
| Fachärztliche Gemeinschaftspraxis Witten | Witten | Germany | Recruiting |
| Petrus-Krankenhaus | Wuppertal | Germany | Recruiting |
| Region Midtjylland | Aarhus N | Denmark | Recruiting |
| Region Hovedstaden | Copenhagen Oe | Denmark | Recruiting |
| Gentofte Hospital | Hellerup | Denmark | Recruiting |
| Region Syddanmark | Odense C | Denmark | Recruiting |
| Hospital Clinic de Barcelona | Barcelona | Spain | Active, not recruiting |
| Hospital Universitari Vall d'Hebron | Barcelona | Spain | Active, not recruiting |
| Bellvitge University Hospital | L'hospitalet De Llobregat | Spain | Active, not recruiting |
| Hospital Universitario de la Princesa | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Virgen de la Victoria | Málaga | Spain | Active, not recruiting |
| Hospital Clinico Universitario de Valencia | Valencia | Spain | Active, not recruiting |
| Centre Hospitalier Universitaire D'Angers | Angers | France | Recruiting |
| Centre Hospitalier Régional et Universitaire de Brest | Brest | France | Recruiting |
| Hospices Civils de Lyon | Bron | France | Recruiting |
| Centre Hospitalier Universitaire de Lille | Lille | France | Recruiting |
| Centre Hospitalier Universitaire de Montpellier | Montpellier | France | Recruiting |
| Centre Hospitalier Universitaire de Nice | Nice | France | Recruiting |
| Assistance Publique Hopitaux De Paris | Paris Cedex 18 | France | Recruiting |
| Centre Hospitalier Universitaire de Rennes | Rennes | France | Recruiting |
| Centre Hospitalier Régional Universitaire de Tours | Tours | France | Recruiting |
| Thoracic General Hospital of Athens "I Sotiria" | Athens | Greece | Recruiting |
| University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA" | Chaïdári | Greece | Recruiting |
| University General Hospital of Heraklion | Heraklion | Greece | Recruiting |
| University General Hospital of Ioannina | Ioannina | Greece | Recruiting |
| General University Hospital Of Patras | Patras | Greece | Recruiting |
| Geniko Nosokomeio Thessalonikis George Papanikolaou | Thessaloniki | Greece | Recruiting |
| Clinic Of Pulmonology Semmelweis University | Budapest Viii | Hungary | Recruiting |
| Orszagos Koranyi Pulmonologiai Intezet | Budapest XII | Hungary | Recruiting |
| University of Debrecen | Debrecen | Hungary | Recruiting |
| Református Pulmonológiai Centrum | Törökbálint | Hungary | Recruiting |
| Azienda Ospedaliero Universitaria Ospedali Riuniti | Foggia | Italy | Recruiting |
| Azienda Unita Sanitaria Locale Della Romagna | Forli' | Italy | Recruiting |
| Azienda Ospedaliero - Universitaria di Modena | Modena | Italy | Recruiting |
| Fondazione IRCCS San Gerardo dei Tintori | Monza | Italy | Recruiting |
| Fondazione IRCCS Policlinico San Matteo | Pavia | Italy | Recruiting |
| Humanitas Mirasole S.p.A. | Rozzano | Italy | Recruiting |
| Azienda Ospedaliero Universitaria Senese | Siena | Italy | Recruiting |
| Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino | Turin | Italy | Recruiting |
| Amsterdam UMC Stichting | Amsterdam | Netherlands | Recruiting |
| Zuyderland Medisch Centrum Stichting | Heerlen | Netherlands | Recruiting |
| Sint Antonius Ziekenhuis Stichting | Nieuwegein | Netherlands | Recruiting |
| Centrum Medycyny Oddechowej Mroz sp. j. | Bialystok | Poland | Recruiting |
| Krakowski Szpital Specjalistyczny Im. Sw. Jana Pawla II | Cracow | Poland | Recruiting |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Uniwersytecki Szpital Kliniczny Nr 1 Im. Norberta Barlickiego Uniwersytetu Medycznego W Lodzi | Lodz | Poland | Recruiting |
| Uniwersytecki Szpital Kliniczny w Poznaniu | Poznan | Poland | Recruiting |
| EMED Centrum Uslug Medycznych Ewa Smialek | Rzeszów | Poland | Recruiting |
| Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji | Warsaw | Poland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.