A study to investigate safety and efficacy of efimosfermin compared with placebo in adult participants with compensated cirrhosis (stage F4 fibrosis) due to MASH (NEBULA-2)

Brief summary (registry, in English)

To determine the effect of efimosfermin compared to placebo on fibrosis improvement of greater than or equal to (>=) 1 stage and no worsening of MASH

What you commit to

• Study type: Interventional · Phase 3
• Planned participants: 69
• 67 sites in 10 countries
• Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.

AI-kivonat: who the study is looking for

Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with compensated cirrhosis (stage 4 fibrosis) caused by MASH, a fatty liver disease linked to metabolic problems.

Age

18 to 75 years

Sex

All sexes can join.

Disease stage

Liver biopsy consistent with cirrhosis (fibrosis stage 4) due to MASH. The cirrhosis must be compensated.

Earlier treatment

Cannot have recent or planned surgery or medicines meant to cause major weight loss.

Biomarker or test result

At least two components of metabolic syndrome, now or in the past. ALT or AST must be below 5 times the upper limit of normal.

Main reasons for not taking part

• Other chronic liver diseases
• Decompensated liver disease or liver cancer (hepatocellular carcinoma)
• Type 1 diabetes, or major complications of Type 2 diabetes
• Chronic pancreatic disease, or pancreatic injury or acute pancreatitis within 6 months before Screening
• Current or past excessive alcohol intake

Read by machine on 9 Nov 2026.

Who cannot take part

Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.

Who the study is looking for

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on EU CTIS (euclinicaltrials.eu)

Sites (67)

Sites in registry order. Save your city in your profile to sort them by distance.

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