2026-527032-14-00RecruitingPhase 4
The RHINOME study
Source: EU CTIS (euclinicaltrials.eu) · Last updated 10 Aug 2026
Brief summary (registry, in English)
To compare epithelial TSLP protein induction following viral mimic stimulation in patients with severe asthma with and without chronic rhinosinusitis.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 72 (estimated)
- First submitted
- 19 Jun 2026
- Start date
- 10 Sept 2026
- Lead sponsor
- Region Hovedstaden
- Diseases
- Asthma
- EU CT number
- 2026-527032-14-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 72
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study design.
AI-kivonat: who the study is looking for
Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with severe asthma. They either are starting tezepelumab or took part in the 3TR-ABC study.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Severe asthma
- Earlier treatment
- Outpatient group: the doctor has decided to start tezepelumab for severe asthma. 3TR-ABC group: finished the 1-year follow-up visit and had nasal and/or bronchial cell samples taken before any biologic treatment.
Main reasons for not taking part
- Known allergy to tezepelumab or anything in it
- Took part in an interventional trial or received an investigational drug within 3 months
- Another serious or uncontrolled illness that may need a change in treatment
- Pregnant or breastfeeding (outpatient group)
- Withdrew consent for future use of samples, or samples of poor quality (3TR-ABC group)
Read by machine on 9 Nov 2026.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Outpatient recruitment pool: 4. Other clinically significant medical disease or uncontrolled concomitant disease likely, in the investigator's opinion, to require a change in therapy or to impair the ability to participate.
Other illness
- Outpatient recruitment pool: 1. Known hypersensitivity to the active substance or any excipient in tezepelumab.
Other
- Outpatient recruitment pool: 2. Participation in an interventional clinical trial within 3 months of the baseline visit, or receipt of any investigational medicinal product within 3 months or 5 half-lives, whichever is longer.
- Outpatient recruitment pool: 3. Participation in other studies that, in the investigator's view, will impact the study outcomes.
- Outpatient recruitment pool: 5. Unwilling or unable, in the investigator's opinion, to participate in study procedures and assessments.
- 3TR-ABC recruitment pool: 1. Known quality issues with airway samples making them insufficient for planned key analyses.
- 3TR-ABC recruitment pool: 2. Any participant who has specifically withdrawn their consent for future use of samples in the 3TR-ABC study.
- Outpatient recruitment pool: 6. Known or suspected pregnancy or breastfeeding, at the baseline (screening) visit. In individuals of childbearing potential, pregnancy is ruled out by a negative urine pregnancy test before inclusion.
Who the study is looking for
- Outpatient recruitment pool: 1. Diagnosed with severe asthma.
- Outpatient recruitment pool: 2. Adult ≥18 years.
- Outpatient recruitment pool: 3. Clinical decision to initiate tezepelumab for severe asthma after meeting licensing, local and national guidelines.
- Outpatient recruitment pool: 4. Able to give valid written informed consent, and compliant with study procedures and study visits.
- 3TR-ABC recruitment pool: 1. 3TR-ABC participant at the Bispebjerg site who completed 1-year follow-up visit.
- 3TR-ABC recruitment pool: 2. Specific bio-sampling for nasal and/or bronchial epithelial cells (NECs and/or BECs) at bio-naïve baseline.
- 3TR-ABC recruitment pool: 3. Able to give valid written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Region Hovedstaden | Copenhagen Nv | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.