NCT00002462Active, not recruitingPhase 3
RT or No RT Following Chemotherapy in Treating Patients With Stage III/IV Hodgkin's Disease
Phase III Randomized Trial of Adjuvant Involved-Field Radiotherapy vs No Adjuvant Therapy Following Remission Induction With MOPP/ABV Hybrid Chemotherapy in Patients With Stage III/IV Hodgkin's Disease
Source: ClinicalTrials.gov · Last updated 5 Aug 2025
Brief summary (registry, in English)
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with combination chemotherapy may kill more tumor cells. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with no radiation therapy following chemotherapy in treating patients with stage III or stage IV Hodgkin's disease.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 615 (actual)
- First submitted
- 1 Nov 1999
- Start date
- Sept 1989
- Primary completion date
- May 2000
- Lead sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
- Diseases
- Hodgkin lymphoma, Childhood cancers
- NCT number
- NCT00002462
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 615
- From Sept 1989 to the primary completion date, May 2000
- 56 sites in 9 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- DISEASE CHARACTERISTICS: Histologically proven clinical or pathological Stage III/IV Hodgkin's disease Pathological Stage IIIAS disease with the spleen as the only site of subdiaphragmatic involvement excluded
- PATIENT CHARACTERISTICS: Age: 15 to 70 Performance status: Not specified Life expectancy: No severe limits on life expectancy due to nonmalignant disease Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Cardiovascular: No severe cardiac disease that would preclude protocol therapy Pulmonary: No severe pulmonary disease that would preclude protocol therapy Other: No severe metabolic or neurologic disease that would preclude protocol therapy No concomitant or previous second malignancy except: Nonmelanomatous skin cancer In situ carcinoma of the cervix
- PRIOR CONCURRENT THERAPY: No prior therapy
Age in the registry: 15 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (56)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Algemeen Ziekenhuis Middelheim Coordinator of this site? Confirm its status | Antwerp | Belgium | Unknown status |
| A.Z. St. Jan Coordinator of this site? Confirm its status | Bruges | Belgium | Unknown status |
| Hopital Universitaire Erasme Coordinator of this site? Confirm its status | Brussels | Belgium | Unknown status |
| Centre Hospitalier Universitaire Brugmann Coordinator of this site? Confirm its status | Brussels (Bruxelles) | Belgium | Unknown status |
| Institut Jules Bordet Coordinator of this site? Confirm its status | Brussels (Bruxelles) | Belgium | Unknown status |
| C.H.U. Saint-Pierre Coordinator of this site? Confirm its status | Brussels (Bruxelles) | Belgium | Unknown status |
| Centre Hospitalier Universitaire de Tivoli Coordinator of this site? Confirm its status | La Louvière | Belgium | Unknown status |
| U.Z. Sint-Rafael Coordinator of this site? Confirm its status | Leuven | Belgium | Unknown status |
| U.Z. Gasthuisberg Coordinator of this site? Confirm its status | Leuven | Belgium | Unknown status |
| Zentralkrankenhaus Coordinator of this site? Confirm its status | Bremen | Germany | Unknown status |
| National Cancer Institute of Egypt Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
| Institut Bergonie Coordinator of this site? Confirm its status | Bordeaux | France | Unknown status |
| Centre Regional Francois Baclesse Coordinator of this site? Confirm its status | Caen | France | Unknown status |
| Centre Hospitalier General Coordinator of this site? Confirm its status | Compiègne | France | Unknown status |
| Centre Georges François Leclerc Coordinator of this site? Confirm its status | Dijon | France | Unknown status |
| Hopital Edouard Herriot Coordinator of this site? Confirm its status | Lyon | France | Unknown status |
| Centre Leon Berard Coordinator of this site? Confirm its status | Lyon | France | Unknown status |
| Centre Antoine Lacassagne Coordinator of this site? Confirm its status | Nice | France | Unknown status |
| Hotel Dieu de Paris Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Hôpital Necker Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Hôpital Cochin Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Hôpital Saint-Antoine Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Hopital Jules Courmont - Centre Hospitalier Lyon Sud Coordinator of this site? Confirm its status | Pierre-Bénite | France | Unknown status |
| Hopital Sud Coordinator of this site? Confirm its status | Rennes | France | Unknown status |
| Centre Henri Becquerel Coordinator of this site? Confirm its status | Rouen | France | Unknown status |
| Centre Medico-Chirurgical Foch Coordinator of this site? Confirm its status | Suresnes | France | Unknown status |
| Centre Alexis Vautrin Coordinator of this site? Confirm its status | Vandœuvre-lès-Nancy | France | Unknown status |
| Institut Gustave Roussy Coordinator of this site? Confirm its status | Villejuif | France | Unknown status |
| Centro di Riferimento Oncologico - Aviano Coordinator of this site? Confirm its status | Aviano | Italy | Unknown status |
| Dipartimente di Oncologia di Torino Coordinator of this site? Confirm its status | Turin (Torino) | Italy | Unknown status |
| Medisch Centrum Alkmaar Coordinator of this site? Confirm its status | Alkmaar | Netherlands | Unknown status |
| Onze Lieve Vrouwe Gasthuis Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Unknown status |
| Integraal Kankercentrum Amsterdam Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Unknown status |
| Slotervaart Ziekenhuis Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Unknown status |
| Antoni van Leeuwenhoekhuis Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Unknown status |
| Streekziekenhuizen Gooi-Noord Coordinator of this site? Confirm its status | Blaricum | Netherlands | Unknown status |
| Catharina Ziekenhuis Coordinator of this site? Confirm its status | Eindhoven | Netherlands | Unknown status |
| Medisch Spectrum Twente Coordinator of this site? Confirm its status | Enschede | Netherlands | Unknown status |
| De Wever Ziekenhuis Coordinator of this site? Confirm its status | Heerlen | Netherlands | Unknown status |
| Radiotherapeutisch Instituut Coordinator of this site? Confirm its status | Leeuwarden | Netherlands | Unknown status |
| Leiden University Medical Center Coordinator of this site? Confirm its status | Leiden | Netherlands | Unknown status |
| Integraal Kankercentrum West Coordinator of this site? Confirm its status | Leiden | Netherlands | Unknown status |
| Academisch Ziekenhuis Maastricht Coordinator of this site? Confirm its status | Maastricht | Netherlands | Unknown status |
| St. Radboud University Hospital Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Unknown status |
| University Hospital - Rotterdam Dijkzigt Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Unknown status |
| Rotterdam Cancer Institute Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Unknown status |
| Leyenburg Ziekenhuis Coordinator of this site? Confirm its status | 's-Gravenhage (Den Haag, the Hague) | Netherlands | Unknown status |
| Groot Ziekengasthuis 's-Hertogenbosch Coordinator of this site? Confirm its status | 's-Hertogenbosch | Netherlands | Unknown status |
| Sophia Ziekehuis Coordinator of this site? Confirm its status | Zwolle | Netherlands | Unknown status |
| Maritime Hospital Coordinator of this site? Confirm its status | Gdynia | Poland | Unknown status |
| Jagiellonian University Coordinator of this site? Confirm its status | Krakow (Cracow) | Poland | Unknown status |
| Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Coordinator of this site? Confirm its status | Warsaw | Poland | Unknown status |
| Hospitais da Universidade de Coimbra (HUC) Coordinator of this site? Confirm its status | Coimbra | Portugal | Unknown status |
| Instituto Portugues de Oncologia de Francisco Gentil Coordinator of this site? Confirm its status | Lisbon | Portugal | Unknown status |
| Instituto Portugues de Oncologia do Porto Coordinator of this site? Confirm its status | Porto | Portugal | Unknown status |
| Institute of Oncology Ljubljana Coordinator of this site? Confirm its status | Ljubljana | Slovenia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.