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NCT00410761CompletedPhase 3

An Efficacy Study Comparing ZD6474 to Placebo in Medullary Thyroid Cancer

An International, Phase III, Randomized, Double-Blinded, Placebo-Controlled, Multi-Center Study to Assess the Efficacy of ZD6474 (ZACTIMATM) Versus Placebo in Subjects With Unresectable Locally Advanced or Metastatic Medullary Thyroid Cancer

Source: ClinicalTrials.gov · Last updated 24 Sept 2025

Brief summary (registry, in English)

The purpose of this study is to learn how hereditary or sporadic medullary thyroid cancer patients, treated with ZD6474, react to the drug, what happens to ZD6474 in the human body, about the side effects of ZD6474, and if ZD6474 can decrease or prevent the growth of tumors.

Status (registry)
Completed
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
331 (actual)
First submitted
6 Dec 2006
Start date
23 Nov 2006
Primary completion date
31 Jul 2009
Lead sponsor
Genzyme, a Sanofi Company
NCT number
NCT00410761
EudraCT number
2005-005077-29

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 331
  • From 23 Nov 2006 to the primary completion date, 31 Jul 2009
  • 85 sites in 24 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Major surgery within 4 weeks before randomization
  • Last dose of prior chemotherapy received less than 4 weeks prior to randomization
  • Radiation therapy within the last 4 weeks prior to randomization(with exception of palliative radiotherapy)
  • Brain metastases or spinal cord compression, unless treated at least 4 weeks before first dose and stable without steroid treatment for 10 days
  • Previous ZD6474 treatment

Other illness

  • Significant cardiac events

Who the study is looking for

  • Confirmed diagnosis of unresectable, locally advanced or metastatic hereditary or sporadic Medullary Thyroid Cancer.
  • Presence of measurable tumor
  • Able to swallow medication

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (85)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
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ViennaAustriaUnknown status
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St LeonardsAustraliaUnknown status
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AnderlechtBelgiumUnknown status
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BrusselsBelgiumUnknown status
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LeuvenBelgiumUnknown status
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Porto AlegreBrazilUnknown status
Hospital De Clinicas De Porto Alegre- Site Number : 2301
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Porto AlegreBrazilUnknown status
Faculdade de Medicina de Ribeirao Preto - USP- Site Number : 2302
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Ribeirão PretoBrazilUnknown status
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Ribeirão PretoBrazilUnknown status
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CalgaryCanadaUnknown status
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LondonCanadaUnknown status
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MonctonCanadaUnknown status
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SherbrookeCanadaUnknown status
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TorontoCanadaUnknown status
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BaselSwitzerlandUnknown status
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BernSwitzerlandUnknown status
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PragueCzechiaUnknown status
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EssenGermanyUnknown status
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HalleGermanyUnknown status
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WürzburgGermanyUnknown status
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Odense CDenmarkUnknown status
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MadridSpainUnknown status
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MadridSpainUnknown status
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PamplonaSpainUnknown status
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BordeauxFranceUnknown status
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LyonFranceUnknown status
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VillejuifFranceUnknown status
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PécsHungaryUnknown status
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MumbaiIndiaUnknown status
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VelloreIndiaUnknown status
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CataniaItalyUnknown status
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MilanItalyUnknown status
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NaplesItalyUnknown status
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PisaItalyUnknown status
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RomaItalyUnknown status
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SienaItalyUnknown status
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SeoulSouth KoreaUnknown status
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Ciudad MaderoMexicoUnknown status
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MéxicoMexicoUnknown status
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Mexico CityMexicoUnknown status
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GroningenNetherlandsUnknown status
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UtrechtNetherlandsUnknown status
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GliwicePolandUnknown status
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PoznanPolandUnknown status
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WarsawPolandUnknown status
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CoimbraPortugalUnknown status
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LisbonPortugalUnknown status
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BucharestRomaniaUnknown status
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BelgradeSerbiaUnknown status
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BelgradeSerbiaUnknown status
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ObninskRussiaUnknown status
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StockholmSwedenUnknown status
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UppsalaSwedenUnknown status
University Of Colorado Health Sciences Center Site Number : 9
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AuroraUnited StatesUnknown status
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AuroraUnited StatesUnknown status
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BostonUnited StatesUnknown status
Dana Farber Cancer Institute Site Number : 2
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BostonUnited StatesUnknown status
Fletcher Allen Health Care Site Number : 21
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BurlingtonUnited StatesUnknown status
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BurlingtonUnited StatesUnknown status
Medical University of South Carolina- Site Number : 19
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CharlestonUnited StatesUnknown status
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CharlestonUnited StatesUnknown status
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ChicagoUnited StatesUnknown status
The University Of Chicago Site Number : 18
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ChicagoUnited StatesUnknown status
University Of Cincinnati Site Number : 6
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CincinnatiUnited StatesUnknown status
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CincinnatiUnited StatesUnknown status
Wayne State University / Harper Hospital Site Number : 7
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DetroitUnited StatesUnknown status
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DetroitUnited StatesUnknown status
Anderson Cancer Center Site Number : 13
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HoustonUnited StatesUnknown status
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HoustonUnited StatesUnknown status
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JacksonvilleUnited StatesUnknown status
Mayo Clinic- Site Number : 15
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JacksonvilleUnited StatesUnknown status
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LexingtonUnited StatesUnknown status
The University Of Kentucky Site Number : 17
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LexingtonUnited StatesUnknown status
University Arkansas Site Number : 3
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Little RockUnited StatesUnknown status
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Little RockUnited StatesUnknown status
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New HavenUnited StatesUnknown status
Yale University School Medicine Site Number : 11
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New HavenUnited StatesUnknown status
Oregon Health & Science University- Site Number : 22
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PortlandUnited StatesUnknown status
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PortlandUnited StatesUnknown status
Mayo Clinic- Site Number : 14
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RochesterUnited StatesUnknown status
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RochesterUnited StatesUnknown status
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San FranciscoUnited StatesUnknown status
USCF / Mt Zion Medical Center Site Number : 8
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San FranciscoUnited StatesUnknown status
Washington University School Of Med Site Number : 10
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St LouisUnited StatesUnknown status
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St LouisUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.