NCT00540761Active, not recruiting
Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging Technique
Natural History of Vulnerable Coronary Plaques
Source: ClinicalTrials.gov · Last updated 22 Oct 2025
Brief summary (registry, in English)
Atherosclerosis, a condition in which fatty deposits of plaque build up along the inner walls of arteries, is a condition that may increase the risk of having a heart attack. Previous studies have shown that the presence of a specific kind of plaque, known as vulnerable plaque, is often found in people who have had a heart attack. This study will use a new imaging technique called optical frequency domain imaging (OFDI) to examine the presence of vulnerable plaques in people with coronary artery disease.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 320 (estimated)
- First submitted
- 24 Sept 2007
- Start date
- 25 Jul 2007
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT00540761
What you commit to
- Study type: Interventional
- Planned participants: 320
- From 25 Jul 2007 to the primary completion date, 31 Dec 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- OR enrolled in another investigational clinical trial within the 6 months prior to study entry
- OR prior coronary artery bypass surgery
Other illness
- OR high-risk and complex lesions, including tortuous blood vessels and lesions with thrombosis
- OR unprotected left main coronary artery disease
- OR severe peripheral vascular disease
- OR congestive heart failure
Lab values
- Kidney insufficiency (i.e., GFR\<50ml/min)
- OR participants who have had a ST elevation heart attack will be excluded for at least 72 hours post-heart attack and until cardiac enzymes return to normal. Participants who have had a non-ST elevation heart attack will be excluded if they have evidence of ongoing ischemia, defined as chest pain or new electrocardiogram (ECG) changes in the 12 hours prior to study entry and/or rising creatine kinase (CK) and CK-MB serum enzymes.
Other
- OR pregnancy
- OR active ischemia
- OR emergent procedures
- OR inability to return for study follow-up procedures
Who the study is looking for
- Undergoing PCTI for coronary artery disease
- Women with childbearing potential must have a negative pregnancy test within the 7 days prior to study entry
Age in the registry: 21 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Lahey Clinic Coordinator of this site? Confirm its status | Burlington | United States | Unknown status |
| Columbia Presbyterian Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.