NCT00571389Recruiting
A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.
A Biospecimen Collection Study to Facilitate Development of an Ex-Vivo Device Platform for Culture, Immune Assay, and Biobanking of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.
Source: ClinicalTrials.gov · Last updated 18 Mar 2026
Brief summary (registry, in English)
Primary Objective: This is a study to investigate the feasibility of harvesting, expanding, and selecting T lymphocytes from cancer patients and healthy volunteers. The preliminary objective of this study is aimed at selecting PD-1+ and CTLA4+ T cells and other cellular fractions from peripheral blood of cancer patients and healthy volunteers by using specific conjugated antibodies, evaluating their functional ex vivo anti-tumor cytotoxicity against targeted autologous tumor cells.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1500 (estimated)
- First submitted
- 10 Dec 2007
- Start date
- Nov 2007
- Primary completion date
- Feb 2030
- Lead sponsor
- BioCytics, Inc.
- Diseases
- Childhood cancers
- NCT number
- NCT00571389
What you commit to
- Study type: Observational
- Planned participants: 1500
- From Nov 2007 to the primary completion date, Feb 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Cancer Cohort Inclusion Criteria:
- Male or Female Adult ≥ 18 years of age.
- Histological diagnosis of any solid tumor type and at any stage of disease progression including in the neoadjuvant/presurgical setting, adjuvant setting, or considered in remission.
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 3 (see Appendix 2) and an estimated life expectancy of at least 3 months.
- Subject or subject's legal representative provides written informed consent.
- Negative serology screening test for HIV, Hepatitis B surface antigen, and Hepatitis C antibody, or negative reflex PCR test result for HIV, Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV)
- Additional eligibility criteria need to be met for leukapheresis collection:
- ECOG Performance Status of 0 or 1 (see Appendix 2)
- WBC ≥2000/μL
- Neutrophils ≥1000/μL
- Platelets ≥100x103/μL
- Hemoglobin ≥9 g/dL
- Creatinine ≤2.5 x ULN
- AST ≤2.5 x ULN without, and ≤ 5 x ULN with hepatic metastases
- Bilirubin ≤2 x ULN (except patients with Gilbert's syndrome, who must have total bilirubin ≤ 3.0 mg/dL)
- Negative urine pregnancy test for women of childbearing potential
- Healthy Volunteer Cohort Inclusion Criteria:
- Male or Female Adult ≥ 18 years of age.
- ▪ Pediatric healthy volunteers from 5-17 years of age, with suspected or confirmed COVID-19 diagnosis by laboratory test will be eligible to participate in minimally invasive biospecimen collection procedures, as long as written parental consent has been obtained, and if applicable and technologically able, child assent. Minimally invasive biospecimen collection procedures allowed for pediatric participation include swabs (nasal, NP and OP), microcapillary sampling, and saliva or urine collection.
- Healthy volunteers are eligible, including the following:
- History of autoimmune disease or inflammatory disorder considered clinically stable by the Principal Investigator or treating physician's discretion.
- Suspected or diagnosed COVID-19 disease by laboratory test, whether in the acute, sub-acute or convalesced state.
- Employees of the study site(s) or BioCytics, as long as fulfilment of inclusion criteria 3.c is obtained.
- Subject or subject's legal representative provides written informed consent.
- Negative serology screening test for HIV, Hepatitis B surface antigen, and Hepatitis C antibody, or negative reflex PCR test result for HIV, HBV, and HCV.
- Additional eligibility criteria need to be met for leukapheresis collection:
- Must be ≥ 18 years of age.
- WBC ≥2000/μL
- Neutrophils ≥1000/μL
- Platelets ≥100x103/μL
- Hemoglobin ≥9 g/dL
- Creatinine ≤2.5 x ULN
- AST ≤2.5 x ULN
- Bilirubin ≤2 x ULN (except patients with Gilbert's syndrome, who must have total bilirubin ≤ 3.0 mg/dL)
- Negative urine pregnancy test for women of childbearing potential
- 2.3.4. Exclusion Criteria
- Subjects with active infection requiring therapy (fever, localizing source) will be excluded until the infection resolves.
- This excludes subjects with suspected or confirmed COVID-19 by laboratory test while in the acute and sub-acute phase of viremia.
- Underlying medical condition that, in the Principal Investigator's or treating oncologist's opinion, will obscure the interpretation of the patient's safety.
- Confirmed positive reflex PCR test result for HIV, Hepatitis B Virus (HBV), or Hepatitis C Virus (HCV).
Age in the registry: 5 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Carolina Biooncology Institute Coordinator of this site? Confirm its status | Huntersville | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.