A Phase II Study of Allo-HCT for B-Cell NHL Using Zevalin, Fludarabine and Melphalan

Prior treatment

• Presence of Human Anti-Zevalin Antibody (HAZA)
• Prior radioimmunotherapy (RIT)
• Prior AHSCT; but prior aHSCT is allowed; prior fractionated total body irradiation (FTBI) in the conditioning regimen will be evaluated on an individual basis

Other illness

• Prior malignancy, except for: adequately treated basal cell or squamous cell skin cancer; adequately treated noninvasive carcinomas; or other cancer from which the patient has been disease-free for at least 5 years; myelodysplastic syndromes (MDS) is excluded from this criterion
• Active evidence of Hepatitis B or C infection; hepatitis B surface antigen positive
• DONOR: HIV infection
• DONOR: Known allergy to G-CSF
• DONOR: Current serious systemic illness or any disease that may preclude the use of G-CSF (eg, recent thromboembolic event); for unrelated donors, considered ineligible by National Marrow Donor Program (NMDP) donor evaluation center

Lab values

• Total peripheral lymphocyte count \> 5,000/mm\^3 if SLL/CLL

Age

• DONOR: Age \< 12 years

Other

• Burkitt lymphoma or Burkitt-like lymphoma
• DONOR: Identical twin
• DONOR: Pregnancy
• DONOR: Inability to achieve adequate venous access

• 6/6/human leukocyte antigen (HLA) matched sibling donor or related donor, or acceptable matched unrelated donor
• Biopsy (Bx) proven diagnosis of LG (including small lymphocytic lymphoma \[SLL\]/chronic lymphocytic leukemia \[CLL\], lymphoplasmacytic lymphoma, marginal zone, mucosa-associated lymphoid tissue \[MALT\] lymphoma and follicular lymphoma \[FL\] grade 1 and 2), IG (FL grade 3 and DLCL) or MCL NHL
• Prior demonstrated monoclonal CD20+ malignant B-Cell population in lymph nodes and/or BM Bx specimen
• LG NHL; must have relapsed after achieving a complete response (CR) or partial response (PR) to prior therapy or have never responded to prior therapy, including chemotherapy and/or MAb therapy
• MCL NHL in any disease state
• Other aggressive B-cell lymphomas (excluding Burkitt lymphoma or Burkitt-like lymphoma) having had at least one relapse or having been refractory to chemotherapy
• Bone marrow (BM) aspiration and Bx ( =\< 42 days prior to imaging dose) which show \< 25% lymphomatous involvement of total cellularity; in CLL, peripheral lymphocyte count \< 5000/mm\^3
• Salvage chemotherapy/MAbs to reduce BM lymphomatous involvement and reduce disease bulk allowed
• Normal renal function test with serum creatinine of =\< 1.5 mg/dl, or a creatinine clearance of \>= 60 ml/min
• Adequate pulmonary function as measured by forced expiratory volume in one second (FEV1) \> 65% of predicted measured, or a diffusing capacity of carbon monoxide (DLCO) \>= 50% of predicted measured
• Cardiac Ejection fraction of \> 50% by Echocardiogram (ECHO) or multi gated acquisition (MUGA)
• Adequate liver function tests with a bilirubin of =\< 1.5 x normal and serum glutamic oxaloacetic transaminase (SGOT) or serum glutamic pyruvic transaminase (SGPT) =\< 2 x normal
• Negative Human Immunodeficiency Virus (HIV) antibody
• Karnofsky Performance Status (KPS) \> 80
• No active Central Nervous System (CNS) disease or prior history of CNS disease
• Involved field External Beam Therapy (EBT) to area excluding lung, heat, liver, and kidney allowed, but evaluated on a case-by-case basis
• Recovery from last therapy and therapy dose (Y-90 Zevalin) must be \>= 4 weeks from prior systemic chemotherapy
• DONOR: Age \< 75 years
• DONOR: HLA genotypically identical related donor or acceptable matched unrelated donor
• DONOR: Must consent to G-CSF administration and leukapheresis for matched sibling donor, but for unrelated donor, the donor will sign a standard consent for donation at their designated donor or collection center
• DONOR: Must have adequate veins for leukapheresis or agree to placement of a Central Venous Catheter (CVC \[femoral, subclavian\])