NCT00582257Completed
Early Onset and Familial Gastric Cancer Registry
Source: ClinicalTrials.gov · Last updated 3 Oct 2024
Brief summary (registry, in English)
The purpose of this study is to establish a gastric cancer registry. A registry is a database of information. With the registry, we can learn more about the genetic causes of gastric cancer in order to develop better methods of early diagnosis, prevention, and treatment of gastric cancers. As part of this study, you will be asked to join a registry of families who are affected with various forms of gastric cancer. These registries are important because they may help physicians better manage gastric cancer now and in the future. Participating in the Early Onset and Familial Gastric Cancer Registry can also be educational for families, since it will provide important information to patients, families, and physicians. All of this will help to further our understanding of genetic causes of gastric cancer and eventually, help determine better ways to diagnose, treat, and survey patients with gastric cancer and people who may have a higher risk for gastric cancer.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 971 (actual)
- First submitted
- 21 Dec 2007
- Start date
- 13 Dec 2005
- Primary completion date
- 30 Sept 2024
- Lead sponsor
- Memorial Sloan Kettering Cancer Center
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT00582257
What you commit to
- Study type: Observational
- Participants enrolled: 971
- From 13 Dec 2005 to the primary completion date, 30 Sept 2024
- 10 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Patient/Relative Cohort:
- Must meet one or more criteria below:
- A person with a diagnosis of gastric or gastroesophageal junction (GEJ) adenocarcinoma confirmed at the treating institution.
- A person without gastric or GEJ adenocarcinoma who has or had a first degree relative eligible for a High Risk Genetic sub-group (EOGC/FGC).
- Early Onset Gastric Cancer - diagnosis of gastric cancer before the age of 50 without a family history of the disease.
- Familial Gastric Cancer - having a family history of gastric cancer as defined as one first degree relative or 2 second degree relatives.
- A person without gastric or GEJ adenocarcinoma who has a personal family history of a genetic mutation associated with the development of gastric or GEJ adenocarcinoma (i.e. family history of CDH1 mutation).
- Must be willing to provide a blood sample for germline DNA. These individuals will sign the "Patient/Relative Consent". Following enrollment, we will assign individuals to the appropriate High Genetic Risk or Low Genetic Risk groups based on the age of diagnosis and their family history.
- Subject Exclusion Criteria
- Patients are ineligible for the study if they:
- Have any condition, which in the opinion of the primary MSK clinician or investigators precludes their ability to provide informed consent.
- Relatives of patients that are not eligible for the High Genetic Risk Cohorts who are less than 18 years of age are excluded.
- Relatives of patients eligible for the High Genetic Risk Cohorts who do not have a proband available to join the study are excluded. (Unless there is a known CDH1 mutation in the family).
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (10)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Obafemi Awolowo University Teaching Hospital Coordinator of this site? Confirm its status | Ile-Ife | Nigeria | Unknown status |
| Memorial Sloan Kettering Cancer Center at Basking Ridge Coordinator of this site? Confirm its status | Basking Ridge | United States | Unknown status |
| Memorial Sloan Kettering Cancer Center at Commack Coordinator of this site? Confirm its status | Commack | United States | Unknown status |
| Memorial Sloan Kettering Westchester Coordinator of this site? Confirm its status | East White Plains | United States | Unknown status |
| Queens Cancer Center of Queens Hospital Coordinator of this site? Confirm its status | Jamaica | United States | Unknown status |
| University of Southern California - Norris Cancer Hospital Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Memorial Sloan Kettering Monmouth Coordinator of this site? Confirm its status | Middletown | United States | Unknown status |
| Weill Cornell Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Memorial Sloan Kettering Cancer Center at Mercy Medical Center Coordinator of this site? Confirm its status | Rockville Centre | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.