NCT00608764Active, not recruiting
Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)
Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD more than others.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 10718 (actual)
- First submitted
- 28 Jan 2008
- Start date
- Nov 2007
- Primary completion date
- Aug 2028
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- COPD
- NCT number
- NCT00608764
What you commit to
- Study type: Observational
- Participants enrolled: 10718
- From Nov 2007 to the primary completion date, Aug 2028
- 20 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cancer (other than skin cancer) in the 5 years prior to study entry
- Received antibiotics for a COPD exacerbation in the 1 month prior to study entry
- First- or second-degree relative of a previously enrolled study participant
Other illness
- Other lung diseases (except for asthma in participants with COPD)
Other
- Pregnant
Who the study is looking for
- At least 10 pack-years of cigarette smoking (although a of nonsmoking controls is also being enrolled)
- Self-designation of non-Hispanic white or African-American
Age in the registry: 45 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (20)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Michigan Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Ann Arbor VA Medical Center Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Morehouse School of Medicine Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Johns Hopkins University Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| National Jewish Health Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Duke University Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| Baylor College of Medicine Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| University of Iowa Coordinator of this site? Confirm its status | Iowa City | United States | Unknown status |
| Minneapolis VA Medical Center Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| HealthPartners Research Foundation Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| University of Minnesota Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Columbia University Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Temple University Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| University of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| University of Texas Health Sciences Center at San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| University of California At San Diego Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| Los Angeles Biomedical Research Institute Coordinator of this site? Confirm its status | Torrance | United States | Unknown status |
| Reliant Medical Group Coordinator of this site? Confirm its status | Worcester | United States | Unknown status |
Related publications
- Plasma proteomic profiles of lung volume-based phenotypes in tobacco-exposed individuals without spirometric chronic obstructive pulmonary disease.Ann Am Thorac Soc · 2026 · PMID 41776818
- High agreement of coronary artery calcification scores between full-dose (6.5 mSv) and reduced-dose (1.5 mSv) chest computed tomography: A retrospective analysis of COPDGene.J Cardiovasc Comput Tomogr · 2026 · PMID 42150985
- Prediction of Lobar Emphysema Progression with a CT-Based Foundational Model.Radiology · 2026 · PMID 42188737
- Multi-trait polygenic scores for COPD and COPD exacerbations implicate druggable proteins.JCI Insight · 2026 · PMID 41712304
- Metformin use and respiratory outcomes in asthma-COPD overlap.Respir Res · 2021 · PMID 33637087
This page is information, not medical advice. Discuss any trial with your doctor.