NCT00673010CompletedPhase 1
Lesion Dosimetry With 124-Iodine in Metastatic Thyroid Carcinoma
Source: ClinicalTrials.gov · Last updated 9 Oct 2025
Brief summary (registry, in English)
One of the most effective treatments for metastases from thyroid cancer is a form of radioactive iodine known as 131-I. For more than 50 years, 131-I has been used to find and destroy thyroid cancer cells that have spread to other parts of the body. In many cases this treatment destroys the metastatic cells. However, in some patients it does not appear to work completely. This study is designed to use a slightly different form of radioactive iodine (called 124-I) which can precisely predict the amount of radiation that each metastatic lesion will receive. 124-I was developed at Memorial Sloan-Kettering in the 1950s and has been used here and at many other medical centers around the world for diagnostic studies. It has been found to be very safe and effective at finding metastatic lesions. The high resolution of newer PET scanners now allows us to carefully determine how much radiation each metastatic lesion will receive. If 124-I can accurately predict which patients will not respond to 131-I treatments we can then avoid exposing those patients to unnecessary radiation. For the rest of the patients we can custom tailor the 131-I dose to destroy the metastatic lesions.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 20 (actual)
- First submitted
- 6 May 2008
- Start date
- 7 Mar 2005
- Primary completion date
- 2 Oct 2025
- Lead sponsor
- Memorial Sloan Kettering Cancer Center
- Diseases
- Thyroid cancer
- NCT number
- NCT00673010
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 20
- From 7 Mar 2005 to the primary completion date, 2 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient who have received a therapeutic dose of radioiodine within the preceding nine months will not be eligible.
- Patients who plan to withdraw from thyroid hormone prior to dosimetry.
Other illness
- Thyroid cancer patients who do not have metastases.
- Thyroid cancer patients who have not demonstrated that their metastases concentrate radioiodine.
- Patients who are under therapy for other active cancers.
Age
- Age less than 18 years.
Other
- Anaplastic or Medullary thyroid carcinoma.
- Patients who are pregnant.
Who the study is looking for
- Adult thyroid carcinoma patients who have had a total thyroidectomy, histology confirmed by an MSKCC attending pathologist, and radioiodine remnant ablation.
- Adult thyroid carcinoma patients who have previously demonstrated radioiodine-avid metastases and are about to undergo Thyrogen-assisted dosimetry at MSKCC.
- The patient and physician are planning to administer 131-I for therapy if persistent radioiodine-avid metastases are present.
- Men and women of all races, ethnicities, and religious backgrounds are eligible.
- All subjects must have measurable disease, documented within the previous six months by ultrasonography (US), MRI, or non-contrast CT scanning.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.