NCT00756769Recruiting
Systemic Lupus Erythematosus in Gullah Health
Source: ClinicalTrials.gov · Last updated 28 Jul 2026
Brief summary (registry, in English)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies, multiple organ involvement, and diverse clinical symptoms and immunologic manifestations. African Americans are at a disproportionately higher risk of developing SLE, develop SLE at an earlier age, and have increased morbidity and mortality compared with European Americans. Our central study hypothesis is that there are specific genetic factors that interact with environmental exposures leading to the development of SLE. The African American Gullah population from the Sea Islands of South Carolina and Georgia are unique in their genetic homogeneity with minimal non-African genetic admixture, making them an ideal cohort to address questions of environmental and genetic influence on the development and progression of SLE.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 750 (estimated)
- First submitted
- 18 Sept 2008
- Start date
- Apr 2003
- Primary completion date
- Jun 2027
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Lupus (SLE)
- NCT number
- NCT00756769
What you commit to
- Study type: Observational
- Planned participants: 750
- From Apr 2003 to the primary completion date, Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Race defined by participant as other than Black or African-American;
- Being a prisoner, mentally ill patient, or institutionalized individual;
- Unwilling or unable to give informed consent
Who the study is looking for
- Age 2 years and above;
- Self-identified as African-American "Gullah" from the Sea Island region of South Carolina;
- Have had at least 4 of the 11 diagnostic criteria for SLE as designated by the American College of Rheumatology (ACR), be a relative of a known SLE patient, or be an unrelated healthy Gullah control;
- Ability to speak and understand English;
- Ability and willingness to give informed consent
Age in the registry: 2 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.