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NCT00759304Active, not recruiting

Evaluation of Aging, Autonomic Nervous System Activity and Cardiovascular Events

Evaluation of Aging, Autonomic Nervous System Activity and Cardiovascular Events on a Prospective Cohort of Subjects Aged 65 Years

Source: ClinicalTrials.gov · Last updated 29 Apr 2025

Brief summary (registry, in English)

The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis. Heart rate fluctuations are highly dependent on ANS control, making the heart one of the best indicators of ANS activity. Low ANS activity level is associated with severe cardiac and cerebral events, as well as to death from any cause in the general population. This PROOF study was hence designed to evaluate ANS activity levels among a healthy retired population, but should these levels decline overtime, to use this as a predictor of cardiovascular and cerebrovascular events, taking into account established cardiovascular risk factors.

Status (registry)
Active, not recruiting
Study type
Observational
Enrollment
1011 (actual)
First submitted
24 Sept 2008
Start date
2 Jan 2000
Primary completion date
Dec 2026
Lead sponsor
Centre Hospitalier Universitaire de Saint Etienne
Diseases
Stroke
NCT number
NCT00759304

What you commit to

  • Study type: Observational
  • Participants enrolled: 1011
  • From 2 Jan 2000 to the primary completion date, Dec 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • prior myocardiac infarction
  • prior stroke

Other illness

  • hearth failure
  • insulin-treated diabetes mellitus
  • cardiac pacemaker

Age

  • disease limiting life expectancy to \< 5 years

Other

  • atrial fibrillation
  • contraindication to brain MRI
  • living in an institution

Who the study is looking for

  • 65 years old
  • informed consent signed

Age in the registry: 65 years to 65 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Centre Hospitalier de Saint-Etienne
Coordinator of this site? Confirm its status
Saint-EtienneFranceUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.