NCT00759304Active, not recruiting
Evaluation of Aging, Autonomic Nervous System Activity and Cardiovascular Events
Evaluation of Aging, Autonomic Nervous System Activity and Cardiovascular Events on a Prospective Cohort of Subjects Aged 65 Years
Source: ClinicalTrials.gov · Last updated 29 Apr 2025
Brief summary (registry, in English)
The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis. Heart rate fluctuations are highly dependent on ANS control, making the heart one of the best indicators of ANS activity. Low ANS activity level is associated with severe cardiac and cerebral events, as well as to death from any cause in the general population. This PROOF study was hence designed to evaluate ANS activity levels among a healthy retired population, but should these levels decline overtime, to use this as a predictor of cardiovascular and cerebrovascular events, taking into account established cardiovascular risk factors.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 1011 (actual)
- First submitted
- 24 Sept 2008
- Start date
- 2 Jan 2000
- Primary completion date
- Dec 2026
- Lead sponsor
- Centre Hospitalier Universitaire de Saint Etienne
- Diseases
- Stroke
- NCT number
- NCT00759304
What you commit to
- Study type: Observational
- Participants enrolled: 1011
- From 2 Jan 2000 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- prior myocardiac infarction
- prior stroke
Other illness
- hearth failure
- insulin-treated diabetes mellitus
- cardiac pacemaker
Age
- disease limiting life expectancy to \< 5 years
Other
- atrial fibrillation
- contraindication to brain MRI
- living in an institution
Who the study is looking for
- 65 years old
- informed consent signed
Age in the registry: 65 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre Hospitalier de Saint-Etienne Coordinator of this site? Confirm its status | Saint-Etienne | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.