NCT00762866Enrolling by invitation
Psychiatric Genotype/Phenotype Project Repository
Psychiatric Genotype/Phenotype Project
Source: ClinicalTrials.gov · Last updated 27 Jan 2026
Brief summary (registry, in English)
The purpose of this project is to obtain DNA, brain imaging data, other biological samples (e.g., urine, serum), and a comprehensive clinical assessment on patients with schizophrenia and other psychotic disorders, bipolar disorder, major depression, and normal volunteer controls. Understanding the physical and genetic factors related to these disorders will help us make progress in fitting treatments to an individual's needs. Participants will take part in a detailed clinical assessment, two blood draws, and an MRI scan over two visits. Participants will also be asked to provide urine and saliva samples.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 2000 (estimated)
- First submitted
- 26 Sept 2008
- Start date
- Sept 2008
- Primary completion date
- Dec 2027
- Lead sponsor
- Vanderbilt University
- Diseases
- Schizophrenia, Depression, Bipolar disorder
- NCT number
- NCT00762866
What you commit to
- Study type: Observational
- Planned participants: 2000
- From Sept 2008 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Dementia or delirium
- Any medical condition that would interfere with participation in the study. This would include, but not be limited to:
- uncontrolled diabetes, hypothyroidism, Cushing's disease, or other significant endocrine condition (treated endocrine condition is allowed)
- demyelinating disease
- HIV infection
- active hepatitis
- CNS infection
- clinically significant and unstable cardiovascular disease
- any cancer involving the CNS (including metastatic disease)
- Exclusion criteria for normal control subjects include any history of mental illness or psychotropic drug abuse.
- Participants will be excluded from the imaging portion of the study if they have any condition deemed to interfere with PET or MRI scanning, such as but not restricted to extreme obesity, metal fragments in eyes, metal implants in the head, or cochlear implant. These participants may still take part in the portion of the study involving the clinical assessment and providing biological samples.
Other
- Reported pregnancy or breastfeeding
Who the study is looking for
- Between the ages of 16 and 65
- Able and willing to provide informed consent
- Able to read and speak English sufficiently to provide consent and answer questions
- Diagnosis of one of the following:
- Unipolar Major Depressive Disorder of any subtype
- Bipolar I, Bipolar II Disorder, or Bipolar Disorder NOS
- Axis I Psychotic Disorder, which can include the diagnoses of Schizophrenia, Schizoaffective Disorder, Major Depression or Mania with Psychotic Features, Schizophreniform Disorder, Brief Psychotic Episode, or Psychotic Disorder NOS
- Normal volunteer controls, individuals with no personal history of any Axis I disorder.
Age in the registry: 16 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.