NCT00765310CompletedPhase 1
Lipoic Acid and Prevention of Heart Disease
The Role of R-alpha Lipoic Acid in Prevention of Atherosclerotic Vascular Disease
Source: ClinicalTrials.gov · Last updated 11 Apr 2025
Brief summary (registry, in English)
The purpose of this study is to see if a dietary supplement, R-alpha lipoic acid, is able to reduce risk factors such as body weight and high blood cholesterol levels in overweight or obese participants.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 81 (actual)
- First submitted
- 1 Oct 2008
- Start date
- 1 Apr 2009
- Primary completion date
- 1 Nov 2011
- Lead sponsor
- Oregon State University
- Diseases
- Obesity
- NCT number
- NCT00765310
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 81
- From 1 Apr 2009 to the primary completion date, 1 Nov 2011
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Having had acute medical conditions, such as hospitalizations or surgeries, at least three months prior to entry into the study
- Currently taking lipid-lowering drugs, anti-hypertensive drugs, insulin , or oral hypoglycemic agents, anti-inflammatory drugs, weight loss medications, or hormone replacement therapy;
- Currently taking vitamin or antioxidant supplements, including R-alpha lipoic acid, except standard multivitamin/mineral supplements containing not more than the Daily Value (DV) of the vitamins and minerals;
Lab values
- Diagnosed as having diabetes (fasting glucose \<125 mg/dl for entry), cardiovascular disease, congestive heart failure, angina, thyroid disorders, cancer, inflammatory disorders or renal, hepatic, or hematological abnormalities;
Other
- Pregnant, breastfeeding, or planning to become pregnant before the end of the study.
- On an extreme diet and not maintaining a prudent diet;
- Smoking within the last three months;
Who the study is looking for
- Age 18-60
- Overweight (BMI, 25.0-29.9 kg/m2) or obese (BMI, \>30 kg/m2);
- Elevated plasma triglycerides (100-400 mg/dl);
- Weight stable for the last three months and at lifetime maximum;
- Exercise limited to 30 minutes 3 times a week or less;
- Hs-CRP level at baseline of ≤ 10 mg/L;
- Consuming ≤ 2 alcoholic drinks per day;
Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Oregon Health Science University Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.